Fenofibrate and Bempedoic Acid Interaction
Drug interaction information between Fenofibrate and Bempedoic Acid.
Fenofibrate and Bempedoic Acid have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fenofibrate and Bempedoic Acid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines can increase the amount of cholesterol that moves into the bile, which may cause gallstones to form.
FDA Label Information
Fibrates Clinical Impact: Both fenofibrate and ezetimibe (a component of NEXLIZET) may increase cholesterol excretion into the bile, leading to cholelithiasis. Coadministration of NEXLIZET with fibrates other than fenofibrate is not recommended [see Adverse Reactions (6.1) ] . Intervention: If cholelithiasis is suspected in a patient receiving NEXLIZET and fenofibrate, gallbladder studies are indicated and alternative lipid-lowering therapy should be considered.
Fenofibrate Also Interacts With
- Cyclosporine moderate
- Colchicine moderate
- Bempedoic Acid/Ezetimibe moderate
- Ezetimibe minor
- Ezetimibe/Simvastatin minor
Bempedoic Acid Also Interacts With
- Simvastatin moderate
- Pravastatin moderate
- Bempedoic Acid/Ezetimibe moderate
- Ezetimibe minor
- Cyclosporine minor
Frequently Asked Questions
What SPL severity band is on file for Fenofibrate + Bempedoic Acid?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fenofibrate has 9 labeled pairs on file vs Bempedoic Acid's 7. In the moderate band specifically: Fenofibrate has 4 (also Cyclosporine, Colchicine, Bempedoic Acid/Ezetimibe); Bempedoic Acid has 4 (also Simvastatin, Pravastatin, Bempedoic Acid/Ezetimibe).
What mechanism field is on file for Fenofibrate and Bempedoic Acid?
Both of these medicines can increase the amount of cholesterol that moves into the bile, which may cause gallstones to form.
Fenofibrate's labeled portfolio outnumbers Bempedoic Acid
SPL source-record counts only. This page's band is moderate · classes on file: Fenofibrate (Fibrate); Bempedoic Acid (ACL Inhibitor).
0 major · 4 moderate · 5 minor · 9 total
- Other moderate peers for Fenofibrate
- Cyclosporine
- Colchicine
- Bempedoic Acid/Ezetimibe
0 major · 4 moderate · 3 minor · 7 total
- Other moderate peers for Bempedoic Acid
- Simvastatin
- Pravastatin
- Bempedoic Acid/Ezetimibe
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.