amlodipine/valsartan vs sildenafil
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Side-by-side comparison of amlodipine/valsartan and sildenafil. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Sildenafil Monitor for hypotension when sildenafil is coadministered with amlodipine [see Clinical Pharmacology (12.2)].
Exforge
Viagra, Revatio
Exforge HCT is a combination medicine used to treat high blood pressure. It contains amlodipine, valsartan, and hydrochlorothiazide to help lower your blood pressure.
Sildenafil is a medicine used to treat erectile dysfunction (ED) in men. It helps increase blood flow to the penis to get and keep an erection.
Exforge HCT is used to treat high blood pressure. Lowering blood pressure reduces the risk of heart problems and strokes. It is for people who need more than one medicine to control their blood pressure. It is not for the initial treatment of high blood pressure.
Sildenafil is used to treat erectile dysfunction (ED), also known as impotence, in men. ED is when you cannot get or keep an erection firm enough for sex. Sildenafil helps by increasing blood flow to the penis when you are sexually stimulated.
This medicine works in three ways to lower blood pressure. Amlodipine relaxes your blood vessels. Valsartan blocks a substance that tightens blood vessels. Hydrochlorothiazide helps your body get rid of extra salt and water.
Sildenafil belongs to a class of drugs called PDE5 inhibitors. It works by relaxing the muscles and increasing blood flow to the penis during sexual stimulation. This helps you get and keep an erection.
- • Dizziness
- • Swelling in your arms, hands, legs, and feet
- • Headache
- • Heartburn
- • Tiredness
- • Headache
- • Flushing (redness of the skin)
- • Upset stomach
- • Abnormal vision (blurred vision, changes in color vision)
- • Nasal congestion (stuffy nose)
- Pain 11
- Interaction with another medicine 9
- Taking too much medicine on purpose 9
- Attempt to end one's own life 9
- Weight loss 9
- Dyspnoea 7,729
- Headache 5,655
- Diarrhoea 4,447
- Nausea 3,984
- Death 3,873
If you are pregnant, stop taking Exforge HCT right away. This medicine can harm or kill your unborn baby.
You should not take sildenafil if you are taking nitrates for chest pain, as this can cause a dangerous drop in blood pressure. If you have an erection that lasts longer than 4 hours, get medical help right away. Stop taking sildenafil and seek medical attention if you have a sudden loss of vision or hearing.
Do not take Exforge HCT if you are pregnant. It can cause serious harm to your unborn baby, including death. Breastfeeding is not recommended while taking this medicine.
Sildenafil is not for use in women. It is not known if sildenafil can harm an unborn baby or pass into breast milk.
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How to Read This amlodipine/valsartan vs sildenafil Comparison
amlodipine/valsartan is classified in the CCB / ARB Combination drug class, while sildenafil sits within the PDE5 Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, amlodipine/valsartan has 47 submissions while sildenafil has 25,688. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to both of these medicines lower blood pressure, and taking them together can cause your blood pressure to drop too low.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for amlodipine/valsartan or sildenafil.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.