Phenelzine and Desvenlafaxine Interaction
Drug interaction information between Phenelzine and Desvenlafaxine.
Phenelzine and Desvenlafaxine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Phenelzine and Desvenlafaxine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications both raise serotonin levels in your body. Combining them can lead to a dangerous condition called serotonin syndrome, which affects your heart rate, blood pressure, and muscles.
FDA Label Information
Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact Concomitant use of PRISTIQ with other serotonergic drugs increases the risk of serotonin syndrome.
Phenelzine Also Interacts With
- Sertraline moderate
- Fluoxetine moderate
- Citalopram moderate
- Venlafaxine moderate
- Fluvoxamine moderate
Desvenlafaxine Also Interacts With
- Aspirin moderate
- Linezolid moderate
- Tranylcypromine moderate
- Selegiline moderate
- Warfarin moderate
Frequently Asked Questions
What SPL severity band is on file for Phenelzine + Desvenlafaxine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenelzine has 27 labeled pairs on file vs Desvenlafaxine's 19. In the moderate band specifically: Phenelzine has 11 (also Sertraline, Fluoxetine, Citalopram, Venlafaxine); Desvenlafaxine has 6 (also Aspirin, Linezolid, Tranylcypromine, Selegiline).
What mechanism field is on file for Phenelzine and Desvenlafaxine?
These medications both raise serotonin levels in your body. Combining them can lead to a dangerous condition called serotonin syndrome, which affects your heart rate, blood pressure, and muscles.
Phenelzine's labeled portfolio outnumbers Desvenlafaxine
SPL source-record counts only. This page's band is moderate · classes on file: Phenelzine (Monoamine Oxidase Inhibitor (MAOI)); Desvenlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
0 major · 11 moderate · 16 minor · 27 total
- Other moderate peers for Phenelzine
- Sertraline
- Fluoxetine
- Citalopram
- Venlafaxine
0 major · 6 moderate · 13 minor · 19 total
- Other moderate peers for Desvenlafaxine
- Aspirin
- Linezolid
- Tranylcypromine
- Selegiline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.