Methylphenidate and Safinamide Interaction
Drug interaction information between Methylphenidate and Safinamide.
Methylphenidate and Safinamide have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Methylphenidate and Safinamide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs both increase certain brain chemicals that can cause your blood pressure to rise to dangerous levels.
FDA Label Information
Concomitant use of XADAGO with methylphenidate, amphetamine, and their derivatives is contraindicated [see Warnings and Precautions (5.1 , 5.2) ] .
Methylphenidate Also Interacts With
- Dexmethylphenidate moderate
- Risperidone moderate
- Linezolid minor
- Phenelzine minor
- Tranylcypromine minor
Safinamide Also Interacts With
- Tramadol major
- Linezolid major
- Methadone major
- Meperidine major
- Dextromethorphan major
Frequently Asked Questions
What SPL severity band is on file for Methylphenidate + Safinamide?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methylphenidate has 11 labeled pairs on file vs Safinamide's 10. In the major band specifically: Methylphenidate has 1; Safinamide has 6 (also Tramadol, Linezolid, Methadone, Meperidine).
What mechanism field is on file for Methylphenidate and Safinamide?
These drugs both increase certain brain chemicals that can cause your blood pressure to rise to dangerous levels.
Safinamide carries more major-labeled pairs than Methylphenidate
SPL source-record counts only. This page's band is major · classes on file: Methylphenidate (CNS Stimulant); Safinamide (MAO-B Inhibitor).
Safinamide has 6 major-labeled pairs vs Methylphenidate's 1.
1 major · 2 moderate · 8 minor · 11 total
Methylphenidate has no other major-band peer in this dataset besides Safinamide.
6 major · 0 moderate · 4 minor · 10 total
- Other major peers for Safinamide
- Tramadol
- Linezolid
- Methadone
- Meperidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.