Methylphenidate and Atomoxetine Interaction
Drug interaction information between Methylphenidate and Atomoxetine.
Methylphenidate and Atomoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Methylphenidate and Atomoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs together does not seem to cause extra stress on the heart compared to taking methylphenidate by itself.
FDA Label Information
7.7 Methylphenidate Coadministration of methylphenidate with atomoxetine did not increase cardiovascular effects beyond those seen with methylphenidate alone.
Methylphenidate Also Interacts With
- Safinamide major
- Dexmethylphenidate moderate
- Risperidone moderate
- Linezolid minor
- Phenelzine minor
Atomoxetine Also Interacts With
- Albuterol moderate
- Omeprazole minor
- Fluoxetine minor
- Warfarin minor
- Diazepam minor
Frequently Asked Questions
What SPL severity band is on file for Methylphenidate + Atomoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Atomoxetine has 15 labeled pairs on file vs Methylphenidate's 11. In the minor band specifically: Methylphenidate has 8 (also Linezolid, Phenelzine, Tranylcypromine, Selegiline); Atomoxetine has 14 (also Omeprazole, Fluoxetine, Warfarin, Diazepam).
What mechanism field is on file for Methylphenidate and Atomoxetine?
Taking these two drugs together does not seem to cause extra stress on the heart compared to taking methylphenidate by itself.
Methylphenidate carries more major-labeled pairs than Atomoxetine
SPL source-record counts only. This page's band is minor · classes on file: Methylphenidate (CNS Stimulant); Atomoxetine (Selective Norepinephrine Reuptake Inhibitor).
Methylphenidate has 1 major-labeled pair vs Atomoxetine's 0. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 8 minor · 11 total
- Other minor peers for Methylphenidate
- Linezolid
- Phenelzine
- Tranylcypromine
- Selegiline
0 major · 1 moderate · 14 minor · 15 total
- Other minor peers for Atomoxetine
- Omeprazole
- Fluoxetine
- Warfarin
- Diazepam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.