Methylphenidate and Phenelzine Interaction
Drug interaction information between Methylphenidate and Phenelzine.
Methylphenidate and Phenelzine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Methylphenidate and Phenelzine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Methylphenidate can raise blood pressure, which makes drugs used to lower blood pressure work less effectively.
FDA Label Information
Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Antihypertensive Drugs Clinical Impact Methylphenidate hydrochloride extended-release capsules may decrease the effectiveness of drugs used to treat hypertension [see Warnings and Precautions ( 5.3 )] .
Methylphenidate Also Interacts With
- Safinamide major
- Dexmethylphenidate moderate
- Risperidone moderate
- Linezolid minor
- Tranylcypromine minor
Phenelzine Also Interacts With
- Sertraline moderate
- Fluoxetine moderate
- Citalopram moderate
- Venlafaxine moderate
- Fluvoxamine moderate
Frequently Asked Questions
What SPL severity band is on file for Methylphenidate + Phenelzine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenelzine has 27 labeled pairs on file vs Methylphenidate's 11. In the minor band specifically: Methylphenidate has 8 (also Linezolid, Tranylcypromine, Selegiline, Atomoxetine); Phenelzine has 16 (also Acetaminophen/Oxycodone, Buprenorphine, Buprenorphine/Naloxone, Buprenorphine).
What mechanism field is on file for Methylphenidate and Phenelzine?
Methylphenidate can raise blood pressure, which makes drugs used to lower blood pressure work less effectively.
Methylphenidate carries more major-labeled pairs than Phenelzine
SPL source-record counts only. This page's band is minor · classes on file: Methylphenidate (CNS Stimulant); Phenelzine (Monoamine Oxidase Inhibitor (MAOI)).
Methylphenidate has 1 major-labeled pair vs Phenelzine's 0. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 8 minor · 11 total
- Other minor peers for Methylphenidate
- Linezolid
- Tranylcypromine
- Selegiline
- Atomoxetine
0 major · 11 moderate · 16 minor · 27 total
- Other minor peers for Phenelzine
- Acetaminophen/Oxycodone
- Buprenorphine
- Buprenorphine/Naloxone
- Buprenorphine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.