Rosuvastatin/Ezetimibe and Fenofibrate Interaction
Drug interaction information between Rosuvastatin/Ezetimibe and Fenofibrate.
Rosuvastatin/Ezetimibe and Fenofibrate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rosuvastatin/Ezetimibe and Fenofibrate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications can both cause muscle problems on their own. Using them at the same time makes it more likely that you will experience muscle damage.
FDA Label Information
Fenofibrates (e.g., fenofibrate and fenofibric acid) Clinical Impact: Fibrates may cause myopathy when given alone.
Rosuvastatin/Ezetimibe Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Rosuvastatin moderate
- Cyclosporine moderate
Fenofibrate Also Interacts With
- Cyclosporine moderate
- Colchicine moderate
- Bempedoic Acid moderate
- Bempedoic Acid/Ezetimibe moderate
- Ezetimibe minor
Frequently Asked Questions
What SPL severity band is on file for Rosuvastatin/Ezetimibe + Fenofibrate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rosuvastatin/Ezetimibe has 12 labeled pairs on file vs Fenofibrate's 9. In the minor band specifically: Rosuvastatin/Ezetimibe has 2 (also Warfarin); Fenofibrate has 5 (also Ezetimibe, Ezetimibe/Simvastatin, Rosuvastatin, Simvastatin).
What mechanism field is on file for Rosuvastatin/Ezetimibe and Fenofibrate?
These medications can both cause muscle problems on their own. Using them at the same time makes it more likely that you will experience muscle damage.
Rosuvastatin/Ezetimibe carries more major-labeled pairs than Fenofibrate
SPL source-record counts only. This page's band is minor · classes on file: Rosuvastatin/Ezetimibe (Statin / Cholesterol Absorption Inhibitor); Fenofibrate (Fibrate).
Rosuvastatin/Ezetimibe has 3 major-labeled pairs vs Fenofibrate's 0. This page itself is in the minor band, not the major band.
3 major · 7 moderate · 2 minor · 12 total
- Other minor peers for Rosuvastatin/Ezetimibe
- Warfarin
0 major · 4 moderate · 5 minor · 9 total
- Other minor peers for Fenofibrate
- Ezetimibe
- Ezetimibe/Simvastatin
- Rosuvastatin
- Simvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.