Rifampin and Aprepitant Interaction
Drug interaction information between Rifampin and Aprepitant.
Rifampin and Aprepitant have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Rifampin and Aprepitant. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin causes your body to process aprepitant much faster than normal, which can make the aprepitant stop working.
FDA Label Information
Intervention Avoid concomitant use of aprepitant Examples rifampin, carbamazepine, phenytoin 7.1 Effect of Aprepitant on the Pharmacokinetics of Other Drugs Aprepitant is a substrate, a weak-to-moderate (dose-dependent) inhibitor, and an inducer of CYP3A4. Intervention Avoid concomitant use of aprepitant Examples rifampin, carbamazepine, phenytoin
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Aprepitant Also Interacts With
- Pimozide major
- Alprazolam moderate
- Diltiazem moderate
- Methylprednisolone moderate
- Ketoconazole moderate
Frequently Asked Questions
What SPL severity band is on file for Rifampin + Aprepitant?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Aprepitant's 22. In the moderate band specifically: Rifampin has 26 (also Doxycycline, Probenecid, Theophylline, Apixaban); Aprepitant has 9 (also Alprazolam, Diltiazem, Methylprednisolone, Ketoconazole).
What mechanism field is on file for Rifampin and Aprepitant?
Rifampin causes your body to process aprepitant much faster than normal, which can make the aprepitant stop working.
Rifampin carries more major-labeled pairs than Aprepitant
SPL source-record counts only. This page's band is moderate · classes on file: Rifampin (Rifamycin Antibiotic); Aprepitant (NK1 Receptor Antagonist (Antiemetic)).
Rifampin has 8 major-labeled pairs vs Aprepitant's 1. This page itself is in the moderate band, not the major band.
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Probenecid
- Theophylline
- Apixaban
1 major · 9 moderate · 12 minor · 22 total
- Other moderate peers for Aprepitant
- Alprazolam
- Diltiazem
- Methylprednisolone
- Ketoconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.