Aprepitant and Pimozide Interaction
Drug interaction information between Aprepitant and Pimozide.
Aprepitant and Pimozide have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Aprepitant and Pimozide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Aprepitant stops the body from breaking down pimozide, which can cause pimozide to build up to dangerous levels in the blood.
Aprepitant Also Interacts With
- Alprazolam moderate
- Diltiazem moderate
- Methylprednisolone moderate
- Ketoconazole moderate
- Clarithromycin moderate
Pimozide Also Interacts With
- Citalopram major
- Clarithromycin major
- Darunavir major
- Escitalopram major
- Fluconazole major
Frequently Asked Questions
What SPL severity band is on file for Aprepitant + Pimozide?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pimozide has 24 labeled pairs on file vs Aprepitant's 22. In the major band specifically: Aprepitant has 1; Pimozide has 12 (also Citalopram, Clarithromycin, Darunavir, Escitalopram).
What mechanism field is on file for Aprepitant and Pimozide?
Aprepitant stops the body from breaking down pimozide, which can cause pimozide to build up to dangerous levels in the blood.
Pimozide carries more major-labeled pairs than Aprepitant
SPL source-record counts only. This page's band is major · classes on file: Aprepitant (NK1 Receptor Antagonist (Antiemetic)); Pimozide (Typical Antipsychotic).
Pimozide has 12 major-labeled pairs vs Aprepitant's 1.
1 major · 9 moderate · 12 minor · 22 total
Aprepitant has no other major-band peer in this dataset besides Pimozide.
12 major · 0 moderate · 12 minor · 24 total
- Other major peers for Pimozide
- Citalopram
- Clarithromycin
- Darunavir
- Escitalopram
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.