Ranolazine and Lovastatin Interaction
Drug interaction information between Ranolazine and Lovastatin.
Ranolazine and Lovastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ranolazine and Lovastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ranolazine can raise the levels of lovastatin in your blood. This increases the risk of a serious muscle condition called rhabdomyolysis.
FDA Label Information
Ranolazine The risk of myopathy, including rhabdomyolysis, may be increased by concomitant administration of ranolazine.
Ranolazine Also Interacts With
- Ketoconazole major
- Carbamazepine major
- Clarithromycin major
- Rifampin major
- Phenytoin major
Lovastatin Also Interacts With
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Spironolactone moderate
- Ketoconazole moderate
- Verapamil moderate
Frequently Asked Questions
What SPL severity band is on file for Ranolazine + Lovastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ranolazine has 31 labeled pairs on file vs Lovastatin's 30. In the moderate band specifically: Ranolazine has 7 (also Empagliflozin, Empagliflozin/Linagliptin, Ertugliflozin, Linagliptin); Lovastatin has 17 (also Spironolactone, Ketoconazole, Verapamil, Cyclosporine).
What mechanism field is on file for Ranolazine and Lovastatin?
Ranolazine can raise the levels of lovastatin in your blood. This increases the risk of a serious muscle condition called rhabdomyolysis.
Ranolazine carries more major-labeled pairs than Lovastatin
SPL source-record counts only. This page's band is moderate · classes on file: Ranolazine (Late Sodium Current Inhibitor (Antianginal)); Lovastatin (HMG-CoA Reductase Inhibitor (Statin)).
Ranolazine has 12 major-labeled pairs vs Lovastatin's 2. This page itself is in the moderate band, not the major band.
12 major · 7 moderate · 12 minor · 31 total
- Other moderate peers for Ranolazine
- Empagliflozin
- Empagliflozin/Linagliptin
- Ertugliflozin
- Linagliptin
2 major · 17 moderate · 11 minor · 30 total
- Other moderate peers for Lovastatin
- Spironolactone
- Ketoconazole
- Verapamil
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.