Ranolazine and Ertugliflozin Interaction
Drug interaction information between Ranolazine and Ertugliflozin.
Ranolazine and Ertugliflozin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ranolazine and Ertugliflozin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ranolazine prevents the kidneys from properly filtering metformin out of the blood, which can lead to a higher amount of metformin in your system.
FDA Label Information
Drugs that Reduce Metformin Clearance Clinical Impact: The risk of lactic acidosis may increase due to concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT2] / multidrug and toxin extrusion [MATE] inhibitors such as ranolazine, vandetanib, dolutegravir, and cimetidine) which increase systemic exposure to metformin Intervention Consider the benefits and risks of concomitant use.
Ranolazine Also Interacts With
- Ketoconazole major
- Carbamazepine major
- Clarithromycin major
- Rifampin major
- Phenytoin major
Ertugliflozin Also Interacts With
- Metformin moderate
- Topiramate moderate
- Dolutegravir moderate
- Cimetidine moderate
- Zonisamide moderate
Frequently Asked Questions
What SPL severity band is on file for Ranolazine + Ertugliflozin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ranolazine has 31 labeled pairs on file vs Ertugliflozin's 8. In the moderate band specifically: Ranolazine has 7 (also Empagliflozin, Empagliflozin/Linagliptin, Linagliptin, Lovastatin); Ertugliflozin has 6 (also Metformin, Topiramate, Dolutegravir, Cimetidine).
What mechanism field is on file for Ranolazine and Ertugliflozin?
Ranolazine prevents the kidneys from properly filtering metformin out of the blood, which can lead to a higher amount of metformin in your system.
Ranolazine carries more major-labeled pairs than Ertugliflozin
SPL source-record counts only. This page's band is moderate · classes on file: Ranolazine (Late Sodium Current Inhibitor (Antianginal)); Ertugliflozin (SGLT2 Inhibitor).
Ranolazine has 12 major-labeled pairs vs Ertugliflozin's 0. This page itself is in the moderate band, not the major band.
12 major · 7 moderate · 12 minor · 31 total
- Other moderate peers for Ranolazine
- Empagliflozin
- Empagliflozin/Linagliptin
- Linagliptin
- Lovastatin
0 major · 6 moderate · 2 minor · 8 total
- Other moderate peers for Ertugliflozin
- Metformin
- Topiramate
- Dolutegravir
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.