Raloxifene and Digoxin Interaction
Drug interaction information between Raloxifene and Digoxin.
Raloxifene and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Raloxifene and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs do not interfere with each other when they are processed by the body.
FDA Label Information
7.5 Other Concomitant Medications Raloxifene hydrochloride can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology (12.3) ] .
Raloxifene Also Interacts With
- Diazepam moderate
- Diazoxide moderate
- Cholestyramine moderate
- Amoxicillin minor
- Warfarin minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Raloxifene + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Raloxifene's 7. In the minor band specifically: Raloxifene has 4 (also Amoxicillin, Warfarin, Famciclovir); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Raloxifene and Digoxin?
These two drugs do not interfere with each other when they are processed by the body.
Digoxin carries more major-labeled pairs than Raloxifene
SPL source-record counts only. This page's band is minor · classes on file: Raloxifene (Selective Estrogen Receptor Modulator (SERM)); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Raloxifene's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 4 minor · 7 total
- Other minor peers for Raloxifene
- Amoxicillin
- Warfarin
- Famciclovir
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.