Raloxifene and Diazepam Interaction
Drug interaction information between Raloxifene and Diazepam.
Raloxifene and Diazepam have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Raloxifene and Diazepam. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both of these drugs like to attach to the same proteins in your blood. Because they compete for the same spots, one drug might get pushed off, leading to higher levels of active medicine in your system.
What To Do
Use this combination with caution. Your doctor should monitor you closely for any increased side effects from either medication.
FDA Label Information
Highly protein-bound drugs include diazepam, diazoxide, and lidocaine. 7.3 Other Highly Protein-Bound Drugs Raloxifene hydrochloride should be used with caution with certain other highly protein-bound drugs such as diazepam, diazoxide, and lidocaine.
Raloxifene Also Interacts With
- Diazoxide moderate
- Cholestyramine moderate
- Amoxicillin minor
- Warfarin minor
- Digoxin minor
Diazepam Also Interacts With
- Clonazepam moderate
- Fluoxetine moderate
- Mirtazapine moderate
- Omeprazole minor
- Ketoconazole minor
Frequently Asked Questions
Can I take Raloxifene and Diazepam together?
This is a moderate interaction. Use this combination with caution. Your doctor should monitor you closely for any increased side effects from either medication.
How serious is the interaction between Raloxifene and Diazepam?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Raloxifene and Diazepam interact?
Both of these drugs like to attach to the same proteins in your blood. Because they compete for the same spots, one drug might get pushed off, leading to higher levels of active medicine in your system.
Understanding the Raloxifene and Diazepam Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Raloxifene belongs to the Selective Estrogen Receptor Modulator (SERM) class and Diazepam belongs to the Benzodiazepine class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both of these drugs like to attach to the same proteins in your blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Raloxifene has 7 total documented interactions on file in this dataset, and Diazepam has 26. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Use this combination with caution. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Raloxifene or Diazepam based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.