Raloxifene and Warfarin Interaction
Drug interaction information between Raloxifene and Warfarin.
Raloxifene and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Raloxifene and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Raloxifene can affect how warfarin thins your blood, which might change your risk of bleeding or blood clots.
FDA Label Information
(7.1 , 12.3) Warfarin : Monitor prothrombin time when starting or stopping raloxifene hydrochloride. 7.2 Warfarin If raloxifene hydrochloride is given concomitantly with warfarin or other warfarin derivatives, prothrombin time should be monitored more closely when starting or stopping therapy with raloxifene hydrochloride [see Clinical Pharmacology (12.3) ] .
Raloxifene Also Interacts With
- Diazepam moderate
- Diazoxide moderate
- Cholestyramine moderate
- Amoxicillin minor
- Digoxin minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Raloxifene + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Raloxifene's 7. In the minor band specifically: Raloxifene has 4 (also Amoxicillin, Digoxin, Famciclovir); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Raloxifene and Warfarin?
Raloxifene can affect how warfarin thins your blood, which might change your risk of bleeding or blood clots.
Warfarin carries more major-labeled pairs than Raloxifene
SPL source-record counts only. This page's band is minor · classes on file: Raloxifene (Selective Estrogen Receptor Modulator (SERM)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Raloxifene's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 4 minor · 7 total
- Other minor peers for Raloxifene
- Amoxicillin
- Digoxin
- Famciclovir
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.