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What the FDA labels say about taking them together

Cholestyramine and raloxifene

Raloxifene's FDA label of April 14, 2026 names cholestyramine in its drug interactions section; the cholestyramine label PlainMeds reads does not name raloxifene. The raloxifene label: “DRUG INTERACTIONS Cholestyramine: Use with EVISTA is not recommended.”

Check it at the source: the cholestyramine FDA label on DailyMed (effective August 20, 2026, AiPing Pharmaceutical, Inc.); the raloxifene FDA label on DailyMed (effective April 14, 2026, Amneal Pharmaceuticals LLC).

What does the cholestyramine label say about raloxifene?

Cholestyramine's label (effective August 20, 2026) does not name raloxifene in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Cholestyramine), AiPing Pharmaceutical, Inc., effective August 20, 2026 (SPL set 214ea05f-de81-4026-9df9-4ce3820668ee), via openFDA; the full label on DailyMed

What does the raloxifene label say about cholestyramine?

Raloxifene label, drug interactions

DRUG INTERACTIONS Cholestyramine: Use with raloxifene hydrochloride is not recommended.

Source: FDA drug label (Evista, NDA020815), Eli Lilly and Company, effective February 11, 2026 (SPL set fcaaa6dc-74e8-4fb8-800c-5574bf0f8de9), via openFDA

Source: FDA drug label (Raloxifene Hydrochloride), Amneal Pharmaceuticals LLC, effective April 14, 2026 (SPL set 3798c70b-a4b0-4811-9788-e4c9cff47ebe), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

15Cholestyramine generic labelers
17Raloxifene generic labelers
CholestyramineRaloxifene
Labeled forHigh cholesterolOsteoporosis, Breast cancer
Boxed warningNoYes
Pharmacy cost (NADAC)$0.834 per packet Cholestyramine packet$0.223 per tablet 60 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?