Raloxifene and Cholestyramine Interaction
Drug interaction information between Raloxifene and Cholestyramine.
Raloxifene and Cholestyramine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Raloxifene and Cholestyramine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cholestyramine can stick to other medicines in your digestive tract and prevent them from being absorbed into your body. This makes the other medicine, like raloxifene, much less effective.
FDA Label Information
7 DRUG INTERACTIONS Cholestyramine : Use with raloxifene hydrochloride is not recommended. (7.3 , 12.3) 7.1 Cholestyramine Concomitant administration of cholestyramine with raloxifene hydrochloride is not recommended.
Raloxifene Also Interacts With
- Diazepam moderate
- Diazoxide moderate
- Amoxicillin minor
- Warfarin minor
- Digoxin minor
Cholestyramine Also Interacts With
- Naproxen moderate
- Olmesartan moderate
- Propranolol minor
- Warfarin minor
- Tetracycline minor
Frequently Asked Questions
What SPL severity band is on file for Raloxifene + Cholestyramine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cholestyramine has 34 labeled pairs on file vs Raloxifene's 7. In the moderate band specifically: Raloxifene has 3 (also Diazepam, Diazoxide); Cholestyramine has 3 (also Naproxen, Olmesartan).
What mechanism field is on file for Raloxifene and Cholestyramine?
Cholestyramine can stick to other medicines in your digestive tract and prevent them from being absorbed into your body. This makes the other medicine, like raloxifene, much less effective.
Cholestyramine's labeled portfolio outnumbers Raloxifene
SPL source-record counts only. This page's band is moderate · classes on file: Raloxifene (Selective Estrogen Receptor Modulator (SERM)); Cholestyramine (Bile Acid Sequestrant).
0 major · 3 moderate · 4 minor · 7 total
0 major · 3 moderate · 31 minor · 34 total
- Other moderate peers for Cholestyramine
- Naproxen
- Olmesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.