Prenatal Multivitamin and Metformin Interaction
Drug interaction information between Prenatal Multivitamin and Metformin.
Prenatal Multivitamin and Metformin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Prenatal Multivitamin and Metformin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Metformin can make it harder for your body to absorb vitamin B12 and can lower the amount of folate in your blood. This may reduce the benefits of the vitamins in your supplement.
FDA Label Information
Metformin treatment in patients with type 2 diabetes decreases serum folate. Drugs which may interact with vitamin B 12 (Methylcobalamin): • Antibiotics, cholestyramine, colchicines, colestipol, metformin, para-aminosalicylic, and potassium chloride may decrease the absorption of vitamin B 12 .
Prenatal Multivitamin Also Interacts With
- Trimethoprim moderate
- Phenytoin moderate
- Fluoxetine minor
- Ibuprofen minor
- Potassium Chloride minor
Metformin Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir moderate
- Dolutegravir/Lamivudine moderate
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
Frequently Asked Questions
What SPL severity band is on file for Prenatal Multivitamin + Metformin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metformin has 27 labeled pairs on file vs Prenatal Multivitamin's 23. In the minor band specifically: Prenatal Multivitamin has 21 (also Fluoxetine, Ibuprofen, Potassium Chloride, Lamotrigine); Metformin has 17 (also Topiramate, Dolutegravir, Ranolazine, Cimetidine).
What mechanism field is on file for Prenatal Multivitamin and Metformin?
Metformin can make it harder for your body to absorb vitamin B12 and can lower the amount of folate in your blood. This may reduce the benefits of the vitamins in your supplement.
Metformin's labeled portfolio outnumbers Prenatal Multivitamin
SPL source-record counts only. This page's band is minor · classes on file: Prenatal Multivitamin (Prenatal Vitamin); Metformin (Biguanide).
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Prenatal Multivitamin
- Fluoxetine
- Ibuprofen
- Potassium Chloride
- Lamotrigine
0 major · 10 moderate · 17 minor · 27 total
- Other minor peers for Metformin
- Topiramate
- Dolutegravir
- Ranolazine
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.