Prenatal Multivitamin and Fluoxetine Interaction
Drug interaction information between Prenatal Multivitamin and Fluoxetine.
Prenatal Multivitamin and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Prenatal Multivitamin and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine can block the system that moves folate from your intestines into your body. This means you might not get the full amount of folate from your multivitamin.
FDA Label Information
• Fluoxetine: Fluoxetine exerts a noncompetitive inhibition of the 5-methyltetrahydrofolate active transport in the intestine.
Prenatal Multivitamin Also Interacts With
- Trimethoprim moderate
- Phenytoin moderate
- Metformin minor
- Ibuprofen minor
- Potassium Chloride minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Prenatal Multivitamin + Fluoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Prenatal Multivitamin's 23. In the minor band specifically: Prenatal Multivitamin has 21 (also Metformin, Ibuprofen, Potassium Chloride, Lamotrigine); Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin).
What mechanism field is on file for Prenatal Multivitamin and Fluoxetine?
Fluoxetine can block the system that moves folate from your intestines into your body. This means you might not get the full amount of folate from your multivitamin.
Fluoxetine carries more major-labeled pairs than Prenatal Multivitamin
SPL source-record counts only. This page's band is minor · classes on file: Prenatal Multivitamin (Prenatal Vitamin); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Prenatal Multivitamin's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Prenatal Multivitamin
- Metformin
- Ibuprofen
- Potassium Chloride
- Lamotrigine
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.