Over-the-counter medication · Prenatal Vitamin
prenatal multivitamin
Also sold as Prenatal Plus. Prenatal Plus helps prevent neural tube defects in babies.
Data updated 2026-05-15
- 23
- InteractionsSeveral interactions
- $0.12
- Generic price (NADAC)
prenatal multivitamin (Prenatal Plus) is an over-the-counter Prenatal Vitamin. Prenatal Plus helps prevent neural tube defects in babies.
Prenatal Plus is a prescription multivitamin with omega-3 and iron. It helps improve nutrition before, during, and after pregnancy.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Generic Price
$0.12/unit
Generic Available
Yes (0 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Prenatal Plus helps prevent neural tube defects in babies.
Common side effects
Allergic reactions, Mild diarrhea, Itching
Key warnings
Accidental overdose of iron can cause fatal poisoning in children under 6.
The sections below are summarized in plain English from prenatal multivitamin's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
This medicine contains L-methylfolate, which helps your body make important substances. It also contains omega-3 fatty acids and iron. These nutrients are important for a healthy pregnancy and baby development.
Serious Warnings
Accidental overdose of iron can cause fatal poisoning in children under 6. Keep this medicine out of reach of children. If a child overdoses, call a doctor or Poison Control Center right away.
Known Drug Interactions
• L-dopa, triamterene, colchicine, and trimethoprim may decrease plasma folate levels. Caution should be exercised with the concomitant use of folinic acid and trimethoprim- sulfamethoxazole for the acute treatment of Pneumocystis carinii pneumonia in patients with HIV infection as it is associated with increased rates of treatment failure and mortality in a placebo-controlled study.
Mechanism: Trimethoprim can lower the amount of folate, an important B-vitamin, in your blood. This can make the folate in your prenatal vitamin less effective.
Drugs which may interact with folate include: • Antiepileptic drugs (AED): The AED class including, but not limited to, phenytoin, carbamazepine, primidone, valproic acid, fosphenytoin, valproate, phenobarbital and lamotrigine have been shown to impair folate absorption and increase the metabolism of circulating folate. • Additionally, concurrent use of folic acid has been associated with enhanced phenytoin metabolism, lowering the level of the AED in the blood and allowing breakthrough seizures to occur. Caution should be used when prescribing this product among patients who are receiving...
Mechanism: The folic acid in the vitamin speeds up how fast your body breaks down the seizure medicine. This can lower the amount of medicine in your blood and make it less effective at preventing seizures.
Metformin treatment in patients with type 2 diabetes decreases serum folate. Drugs which may interact with vitamin B 12 (Methylcobalamin): • Antibiotics, cholestyramine, colchicines, colestipol, metformin, para-aminosalicylic, and potassium chloride may decrease the absorption of vitamin B 12 .
Mechanism: Metformin can make it harder for your body to absorb vitamin B12 and can lower the amount of folate in your blood. This may reduce the benefits of the vitamins in your supplement.
• Fluoxetine: Fluoxetine exerts a noncompetitive inhibition of the 5-methyltetrahydrofolate active transport in the intestine.
Mechanism: Fluoxetine can block the system that moves folate from your intestines into your body. This means you might not get the full amount of folate from your multivitamin.
• NSAIDs include ibuprofen, naproxen, indomethacin and sulindac.
Mechanism: Ibuprofen is a type of NSAID that can interfere with how your body absorbs or uses certain vitamins in your prenatal supplement.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
What if I have a family history of bipolar disorder?
Can this medicine interfere with my seizure medication?
I am undergoing cancer treatment, can I take this?
What if I have anemia?
Can this medicine cause bleeding problems?
What should I tell my doctor before taking this?
What if I am allergic to shellfish?
Who should not take this medicine?
What if I experience side effects?
What does this medicine contain?
What are the common side effects of prenatal multivitamin?
Does prenatal multivitamin interact with other medications?
What drug class is prenatal multivitamin?
What pregnancy or breastfeeding source fields are listed for prenatal multivitamin?
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What the FDA Data Shows for prenatal multivitamin
The FDA label for prenatal multivitamin (sold under brand names such as Prenatal Plus) classifies it as an over-the-counter product in the Prenatal Vitamin class. Prenatal Plus helps prevent neural tube defects in babies. Official labeling lists 11 commonly reported side effects, including Allergic reactions, Mild diarrhea, Itching.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. Voluntary reports accumulate over the lifetime of a drug and reflect wide-ranging clinical use. The database also lists 23 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated moderate severity. NADAC pricing from CMS shows a generic unit cost of $0.12.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: March 10, 2025
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages