Prenatal Multivitamin and Lamotrigine Interaction
Drug interaction information between Prenatal Multivitamin and Lamotrigine.
Prenatal Multivitamin and Lamotrigine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Prenatal Multivitamin and Lamotrigine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This seizure medicine can block your body from absorbing folate and causes your body to break down folate faster than normal.
FDA Label Information
Drugs which may interact with folate include: • Antiepileptic drugs (AED): The AED class including, but not limited to, phenytoin, carbamazepine, primidone, valproic acid, fosphenytoin, valproate, phenobarbital and lamotrigine have been shown to impair folate absorption and increase the metabolism of circulating folate.
Prenatal Multivitamin Also Interacts With
- Trimethoprim moderate
- Phenytoin moderate
- Metformin minor
- Fluoxetine minor
- Ibuprofen minor
Lamotrigine Also Interacts With
- Dofetilide moderate
- Desmopressin moderate
- Valproate minor
- Carbamazepine minor
- Rifampin minor
Frequently Asked Questions
What SPL severity band is on file for Prenatal Multivitamin + Lamotrigine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lamotrigine has 24 labeled pairs on file vs Prenatal Multivitamin's 23. In the minor band specifically: Prenatal Multivitamin has 21 (also Metformin, Fluoxetine, Ibuprofen, Potassium Chloride); Lamotrigine has 22 (also Valproate, Carbamazepine, Rifampin, Phenytoin).
What mechanism field is on file for Prenatal Multivitamin and Lamotrigine?
This seizure medicine can block your body from absorbing folate and causes your body to break down folate faster than normal.
Lamotrigine's labeled portfolio outnumbers Prenatal Multivitamin
SPL source-record counts only. This page's band is minor · classes on file: Prenatal Multivitamin (Prenatal Vitamin); Lamotrigine (Anticonvulsant).
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Prenatal Multivitamin
- Metformin
- Fluoxetine
- Ibuprofen
- Potassium Chloride
0 major · 2 moderate · 22 minor · 24 total
- Other minor peers for Lamotrigine
- Valproate
- Carbamazepine
- Rifampin
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.