acetaminophen/oxycodone vs pregabalin
Side-by-side comparison of acetaminophen/oxycodone and pregabalin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Benzodiazepines and Other Central Nervous System (CNS) Depressants Due to additive pharmacologic effect, the concomitant use of benzodiazepines and other CNS depressants such as benzodiazepines and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death.
Recommendation: Your doctor should monitor you closely for signs of breathing problems or severe drowsiness. Avoid this combination unless your healthcare provider says it is necessary.
Percocet
Lyrica
Percocet is a strong pain medicine. It contains acetaminophen and oxycodone, an opioid.
Pregabalin (Lyrica) is a medicine that can help manage nerve pain, fibromyalgia, and partial-onset seizures. It works by calming overactive nerves in your body.
Percocet is used to manage severe pain. It is for pain that requires an opioid medicine. You should only use Percocet if other pain treatments don't work well enough.
This medicine is used to treat nerve pain caused by diabetes, shingles, or spinal cord injury. It can also help with fibromyalgia, a condition that causes widespread pain. Pregabalin can also be used with other medicines to treat partial-onset seizures in adults and children as young as 1 month old.
Oxycodone works in the brain to block pain signals. Acetaminophen also helps to reduce pain and fever. Together, they provide stronger pain relief.
Pregabalin works by binding to certain areas in your brain and spinal cord. This action helps to reduce the release of chemicals that send pain signals. By reducing these signals, pregabalin can help to lessen pain and control seizures.
- • Lightheadedness
- • Dizziness
- • Drowsiness
- • Nausea
- • Vomiting
- • Dizziness
- • Sleepiness
- • Dry mouth
- • Swelling
- • Blurred vision
- Tiredness 34,486
- Feeling sick to your stomach 29,571
- Head pain 28,378
- Aches 28,322
- Loose stools 23,628
- Pain 25,904
- Tiredness 15,111
- Feeling dizzy 14,526
- Feeling sick to your stomach 14,050
- Headache 12,681
Percocet has a boxed warning. It can cause addiction, abuse, and misuse, leading to overdose and death. It can also cause life-threatening breathing problems, especially when starting or increasing the dose. Accidental ingestion, even one dose, can cause a fatal overdose, especially in children. Taking Percocet with benzodiazepines or other CNS depressants, including alcohol, can cause severe sedation, breathing problems, coma, and death. Using opioids for a long time during pregnancy can cause withdrawal symptoms in the newborn. Acetaminophen can cause liver damage if you take too much.
Pregabalin can cause swelling of the throat, head, and neck, which can be life-threatening. Get emergency help right away if this happens. This medicine can also increase the risk of suicidal thoughts or behavior. Watch for any changes in your mood or behavior. Pregabalin may cause dizziness and sleepiness, so be careful driving or operating machinery. Do not stop taking pregabalin suddenly, as this can cause increased seizures or other side effects.
Taking Percocet for a long time during pregnancy can cause withdrawal symptoms in the baby after birth. Make sure a newborn specialist is available when you deliver your baby.
Taking pregabalin during pregnancy may slightly increase the risk of birth defects. If you are pregnant or plan to become pregnant, talk to your doctor about the risks and benefits of taking this medicine. Breastfeeding while taking pregabalin is not recommended.
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How to Read This acetaminophen/oxycodone vs pregabalin Comparison
acetaminophen/oxycodone is classified in the Opioid Analgesic Combination drug class, while pregabalin sits within the Anticonvulsant / Nerve Pain Agent class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, acetaminophen/oxycodone has 144,385 submissions while pregabalin has 82,272. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to both drugs slow down the central nervous system. using them together can cause extreme sleepiness and make it hard to breathe.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between acetaminophen/oxycodone and pregabalin - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.