Tacrolimus Topical and Estradiol Interaction
Drug interaction information between Tacrolimus Topical and Estradiol.
Tacrolimus Topical and Estradiol have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Tacrolimus Topical and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Estradiol can slow down how your body breaks down tacrolimus, which may increase the amount of medicine in your blood to unsafe levels.
FDA Label Information
Mild or Moderate CYP3A Inhibitors: Clotrimazole, antibiotics (e.g., verapamil, diltiazem, nifedipine, nicardipine), amiodarone, danazol, ethinyl estradiol, cimetidine, lansoprazole and omeprazole May increase tacrolimus whole blood trough concentrations and increase the risk of serious adverse reactions (e.g., neurotoxicity, QT prolongation) [see Warnings and Precautions ( 5.7 , 5.10 , 5.11 )] .
Tacrolimus Topical Also Interacts With
- Omeprazole moderate
- Diltiazem moderate
- Nifedipine moderate
- Ketoconazole moderate
- Verapamil moderate
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Rosuvastatin minor
- Lamotrigine minor
Frequently Asked Questions
What SPL severity band is on file for Tacrolimus Topical + Estradiol?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Tacrolimus Topical's 25. In the moderate band specifically: Tacrolimus Topical has 19 (also Omeprazole, Diltiazem, Nifedipine, Ketoconazole); Estradiol has 3 (also Glecaprevir/Pibrentasvir, Etonogestrel).
What mechanism field is on file for Tacrolimus Topical and Estradiol?
Estradiol can slow down how your body breaks down tacrolimus, which may increase the amount of medicine in your blood to unsafe levels.
Estradiol carries more major-labeled pairs than Tacrolimus Topical
SPL source-record counts only. This page's band is moderate · classes on file: Tacrolimus Topical (Calcineurin Inhibitor (Topical)); Estradiol (Estrogen Hormone).
Estradiol has 1 major-labeled pair vs Tacrolimus Topical's 0. This page itself is in the moderate band, not the major band.
0 major · 19 moderate · 6 minor · 25 total
- Other moderate peers for Tacrolimus Topical
- Omeprazole
- Diltiazem
- Nifedipine
- Ketoconazole
1 major · 3 moderate · 50 minor · 54 total
- Other moderate peers for Estradiol
- Glecaprevir/Pibrentasvir
- Etonogestrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.