Tacrolimus Topical and Omeprazole Interaction
Drug interaction information between Tacrolimus Topical and Omeprazole.
Tacrolimus Topical and Omeprazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Tacrolimus Topical and Omeprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Omeprazole slows down the process your body uses to remove tacrolimus, which can cause the drug to reach risky levels in your blood.
FDA Label Information
Mild or Moderate CYP3A Inhibitors: Clotrimazole, antibiotics (e.g., verapamil, diltiazem, nifedipine, nicardipine), amiodarone, danazol, ethinyl estradiol, cimetidine, lansoprazole and omeprazole May increase tacrolimus whole blood trough concentrations and increase the risk of serious adverse reactions (e.g., neurotoxicity, QT prolongation) [see Warnings and Precautions ( 5.7 , 5.10 , 5.11 )] .
Tacrolimus Topical Also Interacts With
- Estradiol moderate
- Diltiazem moderate
- Nifedipine moderate
- Ketoconazole moderate
- Verapamil moderate
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Aripiprazole minor
Frequently Asked Questions
What SPL severity band is on file for Tacrolimus Topical + Omeprazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Omeprazole has 27 labeled pairs on file vs Tacrolimus Topical's 25. In the moderate band specifically: Tacrolimus Topical has 19 (also Estradiol, Diltiazem, Nifedipine, Ketoconazole); Omeprazole has 4 (also Clarithromycin, Clopidogrel, Darunavir).
What mechanism field is on file for Tacrolimus Topical and Omeprazole?
Omeprazole slows down the process your body uses to remove tacrolimus, which can cause the drug to reach risky levels in your blood.
Omeprazole carries more major-labeled pairs than Tacrolimus Topical
SPL source-record counts only. This page's band is moderate · classes on file: Tacrolimus Topical (Calcineurin Inhibitor (Topical)); Omeprazole (Proton Pump Inhibitor (PPI)).
Omeprazole has 1 major-labeled pair vs Tacrolimus Topical's 0. This page itself is in the moderate band, not the major band.
0 major · 19 moderate · 6 minor · 25 total
- Other moderate peers for Tacrolimus Topical
- Estradiol
- Diltiazem
- Nifedipine
- Ketoconazole
1 major · 4 moderate · 22 minor · 27 total
- Other moderate peers for Omeprazole
- Clarithromycin
- Clopidogrel
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.