Tacrolimus Topical and Diltiazem Interaction
Drug interaction information between Tacrolimus Topical and Diltiazem.
Tacrolimus Topical and Diltiazem have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Tacrolimus Topical and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diltiazem interferes with the way your body processes tacrolimus, which can cause the drug to build up and increase the risk of heart or nerve problems.
FDA Label Information
Mild or Moderate CYP3A Inhibitors: Clotrimazole, antibiotics (e.g., verapamil, diltiazem, nifedipine, nicardipine), amiodarone, danazol, ethinyl estradiol, cimetidine, lansoprazole and omeprazole May increase tacrolimus whole blood trough concentrations and increase the risk of serious adverse reactions (e.g., neurotoxicity, QT prolongation) [see Warnings and Precautions ( 5.7 , 5.10 , 5.11 )] .
Tacrolimus Topical Also Interacts With
- Omeprazole moderate
- Estradiol moderate
- Nifedipine moderate
- Ketoconazole moderate
- Verapamil moderate
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Tacrolimus Topical + Diltiazem?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Tacrolimus Topical's 25. In the moderate band specifically: Tacrolimus Topical has 19 (also Omeprazole, Estradiol, Nifedipine, Ketoconazole); Diltiazem has 7 (also Rifampin, Digoxin, Ivabradine, Aprepitant).
What mechanism field is on file for Tacrolimus Topical and Diltiazem?
Diltiazem interferes with the way your body processes tacrolimus, which can cause the drug to build up and increase the risk of heart or nerve problems.
Diltiazem carries more major-labeled pairs than Tacrolimus Topical
SPL source-record counts only. This page's band is moderate · classes on file: Tacrolimus Topical (Calcineurin Inhibitor (Topical)); Diltiazem (Calcium Channel Blocker).
Diltiazem has 4 major-labeled pairs vs Tacrolimus Topical's 0. This page itself is in the moderate band, not the major band.
0 major · 19 moderate · 6 minor · 25 total
- Other moderate peers for Tacrolimus Topical
- Omeprazole
- Estradiol
- Nifedipine
- Ketoconazole
4 major · 7 moderate · 35 minor · 46 total
- Other moderate peers for Diltiazem
- Rifampin
- Digoxin
- Ivabradine
- Aprepitant
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.