Pioglitazone and Abiraterone Interaction
Drug interaction information between Pioglitazone and Abiraterone.
Pioglitazone and Abiraterone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pioglitazone and Abiraterone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Abiraterone blocks a protein in the liver that normally breaks down pioglitazone. This causes pioglitazone to stay in your body longer and reach higher levels.
FDA Label Information
In a CYP2C8 drug-drug interaction trial in healthy subjects, the AUC of pioglitazone (CYP2C8 substrate) was increased by 46% when pioglitazone was given together with a single dose of 1,000 mg abiraterone acetate.
Pioglitazone Also Interacts With
- Clarithromycin major
- Rifampin minor
- Gemfibrozil minor
- Dapagliflozin minor
- Leflunomide minor
Abiraterone Also Interacts With
- Thioridazine moderate
- Spironolactone (Acne) moderate
- Prednisone minor
- Ketoconazole minor
- Rifampin minor
Frequently Asked Questions
What SPL severity band is on file for Pioglitazone + Abiraterone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pioglitazone has 10 labeled pairs on file vs Abiraterone's 7. In the minor band specifically: Pioglitazone has 9 (also Rifampin, Gemfibrozil, Dapagliflozin, Leflunomide); Abiraterone has 5 (also Prednisone, Ketoconazole, Rifampin, Dextromethorphan).
What mechanism field is on file for Pioglitazone and Abiraterone?
Abiraterone blocks a protein in the liver that normally breaks down pioglitazone. This causes pioglitazone to stay in your body longer and reach higher levels.
Pioglitazone carries more major-labeled pairs than Abiraterone
SPL source-record counts only. This page's band is minor · classes on file: Pioglitazone (Thiazolidinedione); Abiraterone (CYP17 Inhibitor).
Pioglitazone has 1 major-labeled pair vs Abiraterone's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 9 minor · 10 total
- Other minor peers for Pioglitazone
- Rifampin
- Gemfibrozil
- Dapagliflozin
- Leflunomide
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Abiraterone
- Prednisone
- Ketoconazole
- Rifampin
- Dextromethorphan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.