Abiraterone and Thioridazine Interaction
Drug interaction information between Abiraterone and Thioridazine.
Abiraterone and Thioridazine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Abiraterone and Thioridazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Abiraterone interferes with the enzyme that breaks down thioridazine. Because thioridazine has a very narrow safety range, even a small increase in its levels could lead to dangerous side effects.
FDA Label Information
Avoid co-administration of abiraterone acetate with substrates of CYP2D6 with a narrow therapeutic index (e.g., thioridazine).
Abiraterone Also Interacts With
- Spironolactone (Acne) moderate
- Prednisone minor
- Pioglitazone minor
- Ketoconazole minor
- Rifampin minor
Thioridazine Also Interacts With
- Fluoxetine major
- Paroxetine major
- Rolapitant major
- Darifenacin moderate
- Tetrabenazine moderate
Frequently Asked Questions
What SPL severity band is on file for Abiraterone + Thioridazine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Thioridazine has 17 labeled pairs on file vs Abiraterone's 7. In the moderate band specifically: Abiraterone has 2 (also Spironolactone); Thioridazine has 3 (also Darifenacin, Tetrabenazine).
What mechanism field is on file for Abiraterone and Thioridazine?
Abiraterone interferes with the enzyme that breaks down thioridazine. Because thioridazine has a very narrow safety range, even a small increase in its levels could lead to dangerous side effects.
Thioridazine carries more major-labeled pairs than Abiraterone
SPL source-record counts only. This page's band is moderate · classes on file: Abiraterone (CYP17 Inhibitor); Thioridazine (Typical Antipsychotic (Phenothiazine)).
Thioridazine has 3 major-labeled pairs vs Abiraterone's 0. This page itself is in the moderate band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other moderate peers for Abiraterone
- Spironolactone
3 major · 3 moderate · 11 minor · 17 total
- Other moderate peers for Thioridazine
- Darifenacin
- Tetrabenazine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.