Pioglitazone and Dapagliflozin Interaction
Drug interaction information between Pioglitazone and Dapagliflozin.
Pioglitazone and Dapagliflozin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pioglitazone and Dapagliflozin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs do not significantly affect each other's levels in the body.
FDA Label Information
No dosing adjustments required for the following: Oral Antidiabetic Agents Metformin (1000 mg) 20 mg ↔ ↔ Pioglitazone (45 mg) 50 mg ↔ ↔ Sitagliptin (100 mg) 20 mg ↔ ↔ Glimepiride (4 mg) 20 mg ↔ ↔ Voglibose (0.2 mg three times daily) 10 mg ↔ ↔ Other Medications Hydrochlorothiazide (25 mg) 50 mg ↔ ↔ Bumetanide (1 mg) 10 mg once daily for 7 days ↔ ↔ Valsartan (320 mg) 20 mg ↓12% [↓3%, ↓20%] ↔ Simvastatin (40 mg) 20 mg ↔ ↔ Anti-infective Agent Rifampin (600 mg once daily for 6 days) 10 mg ↓7% [↓22%, ↑11%] ↓22% [↓27%, ↓17%] Nonsteroidal Anti-inflammatory Agent Mefenamic Acid (loading dose of...
Pioglitazone Also Interacts With
- Clarithromycin major
- Rifampin minor
- Gemfibrozil minor
- Abiraterone minor
- Leflunomide minor
Dapagliflozin Also Interacts With
- Metformin minor
- Hydrochlorothiazide minor
- Simvastatin minor
- Glimepiride minor
- Valsartan minor
Frequently Asked Questions
What SPL severity band is on file for Pioglitazone + Dapagliflozin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dapagliflozin has 13 labeled pairs on file vs Pioglitazone's 10. In the minor band specifically: Pioglitazone has 9 (also Rifampin, Gemfibrozil, Abiraterone, Leflunomide); Dapagliflozin has 13 (also Metformin, Hydrochlorothiazide, Simvastatin, Glimepiride).
What mechanism field is on file for Pioglitazone and Dapagliflozin?
These drugs do not significantly affect each other's levels in the body.
Pioglitazone carries more major-labeled pairs than Dapagliflozin
SPL source-record counts only. This page's band is minor · classes on file: Pioglitazone (Thiazolidinedione); Dapagliflozin (SGLT2 Inhibitor).
Pioglitazone has 1 major-labeled pair vs Dapagliflozin's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 9 minor · 10 total
- Other minor peers for Pioglitazone
- Rifampin
- Gemfibrozil
- Abiraterone
- Leflunomide
0 major · 0 moderate · 13 minor · 13 total
- Other minor peers for Dapagliflozin
- Metformin
- Hydrochlorothiazide
- Simvastatin
- Glimepiride
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.