Pioglitazone and Dapagliflozin Interaction
Drug interaction information between Pioglitazone and Dapagliflozin.
Pioglitazone and Dapagliflozin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pioglitazone and Dapagliflozin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These drugs do not significantly affect each other's levels in the body.
What To Do
No dose changes are needed when taking these two medications together.
FDA Label Information
No dosing adjustments required for the following: Oral Antidiabetic Agents Metformin (1000 mg) 20 mg ↔ ↔ Pioglitazone (45 mg) 50 mg ↔ ↔ Sitagliptin (100 mg) 20 mg ↔ ↔ Glimepiride (4 mg) 20 mg ↔ ↔ Voglibose (0.2 mg three times daily) 10 mg ↔ ↔ Other Medications Hydrochlorothiazide (25 mg) 50 mg ↔ ↔ Bumetanide (1 mg) 10 mg once daily for 7 days ↔ ↔ Valsartan (320 mg) 20 mg ↓12% [↓3%, ↓20%] ↔ Simvastatin (40 mg) 20 mg ↔ ↔ Anti-infective Agent Rifampin (600 mg once daily for 6 days) 10 mg ↓7% [↓22%, ↑11%] ↓22% [↓27%, ↓17%] Nonsteroidal Anti-inflammatory Agent Mefenamic Acid (loading dose of...
Pioglitazone Also Interacts With
- Clarithromycin major
- Rifampin minor
- Gemfibrozil minor
- Abiraterone minor
- Leflunomide minor
Dapagliflozin Also Interacts With
- Metformin minor
- Hydrochlorothiazide minor
- Simvastatin minor
- Glimepiride minor
- Valsartan minor
Frequently Asked Questions
Can I take Pioglitazone and Dapagliflozin together?
This is a minor interaction. No dose changes are needed when taking these two medications together.
How serious is the interaction between Pioglitazone and Dapagliflozin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Pioglitazone and Dapagliflozin interact?
These drugs do not significantly affect each other's levels in the body.
Understanding the Pioglitazone and Dapagliflozin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Pioglitazone belongs to the Thiazolidinedione class and Dapagliflozin belongs to the SGLT2 Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These drugs do not significantly affect each other's levels in the body. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Pioglitazone has 10 total documented interactions on file in this dataset, and Dapagliflozin has 13. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: No dose changes are needed when taking these two medications together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Pioglitazone or Dapagliflozin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.