Abiraterone and Rifampin Interaction
Drug interaction information between Abiraterone and Rifampin.
Abiraterone and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Abiraterone and Rifampin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Rifampin makes your liver work faster to get rid of abiraterone. This lowers the amount of abiraterone in your blood, which could make it less effective.
What To Do
Your doctor may need to increase your dose of abiraterone or choose a different medication.
FDA Label Information
In a dedicated drug interaction trial, co-administration of rifampin, a strong CYP3A4 inducer, decreased exposure of abiraterone by 55%.
Abiraterone Also Interacts With
- Thioridazine moderate
- Spironolactone (Acne) moderate
- Prednisone minor
- Pioglitazone minor
- Ketoconazole minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
Can I take Abiraterone and Rifampin together?
This is a minor interaction. Your doctor may need to increase your dose of abiraterone or choose a different medication.
How serious is the interaction between Abiraterone and Rifampin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Abiraterone and Rifampin interact?
Rifampin makes your liver work faster to get rid of abiraterone. This lowers the amount of abiraterone in your blood, which could make it less effective.
Understanding the Abiraterone and Rifampin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Abiraterone belongs to the CYP17 Inhibitor class and Rifampin belongs to the Rifamycin Antibiotic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Rifampin makes your liver work faster to get rid of abiraterone. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Abiraterone has 7 total documented interactions on file in this dataset, and Rifampin has 137. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to increase your dose of abiraterone or choose a different medication. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Abiraterone or Rifampin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.