What the FDA labels say about taking them together
Pioglitazone and rifampin
Pioglitazone's FDA label of March 28, 2025 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name pioglitazone. The pioglitazone label: “CYP2C8 inducers (e.g., rifampin) may decrease pioglitazone concentrations.”
Check it at the source: the pioglitazone FDA label on DailyMed (effective March 28, 2025, Takeda Pharmaceuticals America, Inc.); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the pioglitazone label say about rifampin?
Pioglitazone label, drug interactionsCYP2C8 inducers (e.g., rifampin) may decrease pioglitazone concentrations.
Source: FDA drug label (Actos), Takeda Pharmaceuticals America, Inc., effective March 28, 2025 (SPL set d2ddc491-88a9-4063-9150-443b4fa4330c), via openFDA; the full label on DailyMed
What does the rifampin label say about pioglitazone?
Rifampin's label (effective February 11, 2026) does not name pioglitazone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pioglitazone | Rifampin | |
|---|---|---|
| Labeled for | Type 2 diabetes | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0675 per tablet 15 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once