Pioglitazone and Rifampin Interaction
Drug interaction information between Pioglitazone and Rifampin.
Pioglitazone and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pioglitazone and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin makes your body get rid of pioglitazone much faster than usual. This lowers the amount of medicine in your body and makes it less effective at controlling blood sugar.
FDA Label Information
(2.3 , 7.1) CYP2C8 inducers (e.g., rifampin) may decrease pioglitazone concentrations. 7.2 CYP2C8 Inducers An inducer of CYP2C8 (e.g., rifampin) may significantly decrease the exposure (AUC) of pioglitazone.
Pioglitazone Also Interacts With
- Clarithromycin major
- Gemfibrozil minor
- Abiraterone minor
- Dapagliflozin minor
- Leflunomide minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Pioglitazone + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Pioglitazone's 10. In the minor band specifically: Pioglitazone has 9 (also Gemfibrozil, Abiraterone, Dapagliflozin, Leflunomide); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Pioglitazone and Rifampin?
Rifampin makes your body get rid of pioglitazone much faster than usual. This lowers the amount of medicine in your body and makes it less effective at controlling blood sugar.
Rifampin carries more major-labeled pairs than Pioglitazone
SPL source-record counts only. This page's band is minor · classes on file: Pioglitazone (Thiazolidinedione); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Pioglitazone's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 9 minor · 10 total
- Other minor peers for Pioglitazone
- Gemfibrozil
- Abiraterone
- Dapagliflozin
- Leflunomide
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.