Abiraterone and Prednisone Interaction
Drug interaction information between Abiraterone and Prednisone.
Abiraterone and Prednisone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Abiraterone and Prednisone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs together can change how your liver processes other common medications, potentially causing those other drugs to build up in your system.
FDA Label Information
In a CYP2D6 drug-drug interaction trial, the C max and AUC of dextromethorphan (CYP2D6 substrate) were increased 2.8- and 2.9-fold, respectively, when dextromethorphan was given with abiraterone acetate 1,000 mg daily and prednisone 5 mg twice daily.
Abiraterone Also Interacts With
- Thioridazine moderate
- Spironolactone (Acne) moderate
- Pioglitazone minor
- Ketoconazole minor
- Rifampin minor
Prednisone Also Interacts With
- Theophylline major
- Darunavir minor
- Dolutegravir minor
- Fluconazole minor
- Montelukast minor
Frequently Asked Questions
What SPL severity band is on file for Abiraterone + Prednisone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Prednisone has 9 labeled pairs on file vs Abiraterone's 7. In the minor band specifically: Abiraterone has 5 (also Pioglitazone, Ketoconazole, Rifampin, Dextromethorphan); Prednisone has 8 (also Darunavir, Dolutegravir, Fluconazole, Montelukast).
What mechanism field is on file for Abiraterone and Prednisone?
Taking these two drugs together can change how your liver processes other common medications, potentially causing those other drugs to build up in your system.
Prednisone carries more major-labeled pairs than Abiraterone
SPL source-record counts only. This page's band is minor · classes on file: Abiraterone (CYP17 Inhibitor); Prednisone (Corticosteroid).
Prednisone has 1 major-labeled pair vs Abiraterone's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Abiraterone
- Pioglitazone
- Ketoconazole
- Rifampin
- Dextromethorphan
1 major · 0 moderate · 8 minor · 9 total
- Other minor peers for Prednisone
- Darunavir
- Dolutegravir
- Fluconazole
- Montelukast
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.