What the FDA labels say about taking them together
Abiraterone and prednisone
Abiraterone's FDA label of March 28, 2025 names prednisone in its drug interactions section; the prednisone label PlainMeds reads does not name abiraterone. The abiraterone label: “… when dextromethorphan was given with abiraterone acetate 1,000 mg daily and prednisone 5 mg twice daily.”
Check it at the source: the abiraterone FDA label on DailyMed (effective March 28, 2025, Janssen Biotech, Inc.); the prednisone FDA label on DailyMed (effective April 22, 2025, Hikma Pharmaceuticals USA Inc.).
What does the abiraterone label say about prednisone?
Abiraterone label, drug interactionsIn a CYP2D6 drug-drug interaction trial, the C max and AUC of dextromethorphan (CYP2D6 substrate) were increased 2.8- and 2.9-fold, respectively, when dextromethorphan was given with abiraterone acetate 1,000 mg daily and prednisone 5 mg twice daily.
Abiraterone label, warnings and precautionsUse of ZYTIGA plus prednisone/prednisolone in combination with radium Ra 223 dichloride is not recommended.
Source: FDA drug label (Zytiga), Janssen Biotech, Inc., effective March 28, 2025 (SPL set 4e338e89-3cf2-48eb-b6e2-a06c608c6513), via openFDA; the full label on DailyMed
What does the prednisone label say about abiraterone?
Prednisone's label (effective April 22, 2025) does not name abiraterone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PredniSONE), Hikma Pharmaceuticals USA Inc., effective April 22, 2025 (SPL set 3115aef0-fd50-4ec8-a064-3effb695f3f2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Abiraterone | Prednisone | |
|---|---|---|
| Labeled for | Prostate cancer | Osteoarthritis, Asthma, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Multiple sclerosis, Eczema (atopic dermatitis), Anemia, Organ transplant rejection |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.774 per tablet 250 mg tablet | $0.0643 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once