Pioglitazone and Gemfibrozil Interaction
Drug interaction information between Pioglitazone and Gemfibrozil.
Pioglitazone and Gemfibrozil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pioglitazone and Gemfibrozil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Gemfibrozil blocks the liver enzyme that breaks down pioglitazone, which causes the drug to stay in your body longer and reach higher levels.
FDA Label Information
7 DRUG INTERACTIONS Strong CYP2C8 inhibitors (e.g., gemfibrozil) increase pioglitazone concentrations. ( 7.3 ) 7.1 Strong CYP2C8 Inhibitors An inhibitor of CYP2C8 (e.g., gemfibrozil) significantly increases the exposure (area under the serum concentration-time curve or AUC) and half-life (t 1/2 ) of pioglitazone. Therefore, the maximum recommended dose of pioglitazone is 15 mg daily if used in combination with gemfibrozil or other strong CYP2C8 inhibitors [see Dosage and Administration (2.3) and Clinical Pharmacology (12.3) ].
Pioglitazone Also Interacts With
- Clarithromycin major
- Rifampin minor
- Abiraterone minor
- Dapagliflozin minor
- Leflunomide minor
Gemfibrozil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Repaglinide major
- Simvastatin major
- Atorvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Pioglitazone + Gemfibrozil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Gemfibrozil has 20 labeled pairs on file vs Pioglitazone's 10. In the minor band specifically: Pioglitazone has 9 (also Rifampin, Abiraterone, Dapagliflozin, Leflunomide); Gemfibrozil has 8 (also Colchicine, Colestipol, Enzalutamide, Metformin/Pioglitazone).
What mechanism field is on file for Pioglitazone and Gemfibrozil?
Gemfibrozil blocks the liver enzyme that breaks down pioglitazone, which causes the drug to stay in your body longer and reach higher levels.
Gemfibrozil carries more major-labeled pairs than Pioglitazone
SPL source-record counts only. This page's band is minor · classes on file: Pioglitazone (Thiazolidinedione); Gemfibrozil (Fibrate).
Gemfibrozil has 4 major-labeled pairs vs Pioglitazone's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 9 minor · 10 total
- Other minor peers for Pioglitazone
- Rifampin
- Abiraterone
- Dapagliflozin
- Leflunomide
4 major · 8 moderate · 8 minor · 20 total
- Other minor peers for Gemfibrozil
- Colchicine
- Colestipol
- Enzalutamide
- Metformin/Pioglitazone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.