What the FDA labels say about taking them together
Gemfibrozil and pioglitazone
Gemfibrozil's FDA label of April 10, 2026 names pioglitazone in its drug interactions section, and pioglitazone's label names gemfibrozil too. The pioglitazone label: “Strong CYP2C8 inhibitors (e.g., gemfibrozil) increase pioglitazone concentrations.”
Check it at the source: the gemfibrozil FDA label on DailyMed (effective April 10, 2026, Northstar RxLLC); the pioglitazone FDA label on DailyMed (effective March 28, 2025, Takeda Pharmaceuticals America, Inc.).
What does the gemfibrozil label say about pioglitazone?
Gemfibrozil label, drug interactions(C) CYP2C8 Substrates: Gemfibrozil is a strong inhibitor of CYP2C8 and may increase exposure of drugs mainly metabolized by CYP2C8 (e.g., dabrafenib, enzalutamide, loperamide, montelukast, paclitaxel, pioglitazone, rosiglitazone).
Source: FDA drug label (Gemfibrozil), Northstar RxLLC, effective April 10, 2026 (SPL set 75cac02c-56e3-4dfe-b1e2-4ce166b28833), via openFDA; the full label on DailyMed
What does the pioglitazone label say about gemfibrozil?
Pioglitazone label, drug interactionsStrong CYP2C8 inhibitors (e.g., gemfibrozil) increase pioglitazone concentrations.
Source: FDA drug label (Actos), Takeda Pharmaceuticals America, Inc., effective March 28, 2025 (SPL set d2ddc491-88a9-4063-9150-443b4fa4330c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Gemfibrozil | Pioglitazone | |
|---|---|---|
| Labeled for | High cholesterol, Heart attack and coronary artery disease | Type 2 diabetes |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.104 per tablet 600 mg tablet | $0.0675 per tablet 15 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once