Abiraterone and Ketoconazole Interaction
Drug interaction information between Abiraterone and Ketoconazole.
Abiraterone and Ketoconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Abiraterone and Ketoconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Ketoconazole does not change how your body processes abiraterone. There is no significant interaction between these two drugs.
What To Do
You can take these medications together without any special changes to your treatment.
FDA Label Information
In a dedicated drug interaction trial, co-administration of ketoconazole, a strong inhibitor of CYP3A4, had no clinically meaningful effect on the pharmacokinetics of abiraterone [see Clinical Pharmacology ( 12.3 )].
Abiraterone Also Interacts With
- Thioridazine moderate
- Spironolactone (Acne) moderate
- Prednisone minor
- Pioglitazone minor
- Rifampin minor
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
Can I take Abiraterone and Ketoconazole together?
This is a minor interaction. You can take these medications together without any special changes to your treatment.
How serious is the interaction between Abiraterone and Ketoconazole?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Abiraterone and Ketoconazole interact?
Ketoconazole does not change how your body processes abiraterone. There is no significant interaction between these two drugs.
Understanding the Abiraterone and Ketoconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Abiraterone belongs to the CYP17 Inhibitor class and Ketoconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Ketoconazole does not change how your body processes abiraterone. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Abiraterone has 7 total documented interactions on file in this dataset, and Ketoconazole has 113. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You can take these medications together without any special changes to your treatment. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Abiraterone or Ketoconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.