Abiraterone and Dextromethorphan Interaction
Drug interaction information between Abiraterone and Dextromethorphan.
Abiraterone and Dextromethorphan have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Abiraterone and Dextromethorphan. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Abiraterone stops your body from breaking down dextromethorphan normally. This causes the amount of dextromethorphan in your blood to increase significantly.
FDA Label Information
In a CYP2D6 drug-drug interaction trial, the C max and AUC of dextromethorphan (CYP2D6 substrate) were increased 2.8- and 2.9-fold, respectively, when dextromethorphan was given with abiraterone acetate 1,000 mg daily and prednisone 5 mg twice daily.
Abiraterone Also Interacts With
- Thioridazine moderate
- Spironolactone (Acne) moderate
- Prednisone minor
- Pioglitazone minor
- Ketoconazole minor
Dextromethorphan Also Interacts With
- Safinamide major
- Memantine moderate
- Rasagiline moderate
- Tranylcypromine moderate
- Aripiprazole minor
Frequently Asked Questions
What SPL severity band is on file for Abiraterone + Dextromethorphan?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dextromethorphan has 15 labeled pairs on file vs Abiraterone's 7. In the minor band specifically: Abiraterone has 5 (also Prednisone, Pioglitazone, Ketoconazole, Rifampin); Dextromethorphan has 11 (also Aripiprazole, Brexpiprazole, Desvenlafaxine, Fluvoxamine).
What mechanism field is on file for Abiraterone and Dextromethorphan?
Abiraterone stops your body from breaking down dextromethorphan normally. This causes the amount of dextromethorphan in your blood to increase significantly.
Dextromethorphan carries more major-labeled pairs than Abiraterone
SPL source-record counts only. This page's band is minor · classes on file: Abiraterone (CYP17 Inhibitor); Dextromethorphan (Antitussive).
Dextromethorphan has 1 major-labeled pair vs Abiraterone's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Abiraterone
- Prednisone
- Pioglitazone
- Ketoconazole
- Rifampin
1 major · 3 moderate · 11 minor · 15 total
- Other minor peers for Dextromethorphan
- Aripiprazole
- Brexpiprazole
- Desvenlafaxine
- Fluvoxamine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.