What the FDA labels say about taking them together
Abiraterone and dextromethorphan
Abiraterone's FDA label of March 28, 2025 names dextromethorphan in its drug interactions section; the dextromethorphan label PlainMeds reads does not name abiraterone. The abiraterone label: “In a CYP2D6 drug-drug interaction trial, the C max and AUC of dextromethorphan (CYP2D6 substrate) were increased 2.8- and 2.9-fold, respectively, when dextromethorphan was given with abiraterone acetate 1,000 mg daily …”
Check it at the source: the abiraterone FDA label on DailyMed (effective March 28, 2025, Janssen Biotech, Inc.); the dextromethorphan FDA label on DailyMed (effective August 27, 2026).
What does the abiraterone label say about dextromethorphan?
Abiraterone label, drug interactionsIn a CYP2D6 drug-drug interaction trial, the C max and AUC of dextromethorphan (CYP2D6 substrate) were increased 2.8- and 2.9-fold, respectively, when dextromethorphan was given with abiraterone acetate 1,000 mg daily and prednisone 5 mg twice daily.
Source: FDA drug label (Zytiga), Janssen Biotech, Inc., effective March 28, 2025 (SPL set 4e338e89-3cf2-48eb-b6e2-a06c608c6513), via openFDA; the full label on DailyMed
What does the dextromethorphan label say about abiraterone?
Dextromethorphan's label (effective August 27, 2026) does not name abiraterone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Good Sense Cough DM), L. Perrigo Company, effective August 27, 2026 (SPL set 5a2e9bef-42cb-4b72-9a26-c3ae71dcb4ea), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Abiraterone | Dextromethorphan | |
|---|---|---|
| Labeled for | Prostate cancer | Cough and cold |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.774 per tablet 250 mg tablet | $0.122 per unit 15 mg softgel |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once