What the FDA labels say about taking them together
Nitroglycerin and tadalafil
Nitroglycerin's FDA label of February 15, 2023 names tadalafil in its contraindications section, and tadalafil's label names nitroglycerin too. The nitroglycerin label: “Do not use NITRO-DUR in patients who are taking phosphodiesterase inhibitors for erectile dysfunction or pulmonary arterial hypertension.”
Check it at the source: the nitroglycerin FDA label on DailyMed (effective February 15, 2023, Viatris Specialty LLC); the tadalafil FDA label on DailyMed (effective June 3, 2026, Eli Lilly and Company).
What does the nitroglycerin label say about tadalafil?
Nitroglycerin label, contraindicationsUse of phosphodiesterase type 5 (PDE-5) inhibitors, such as avanafil, sildenafil, tadalafil, or vardenafil, or soluble guanylate cyclase (sGC) stimulators.
Nitroglycerin label, drug interactionsPDE-5-Inhibitors such as avanafil, sildenafil, vardenafil, and tadalafil have been shown to potentiate the hypotensive effects of organic nitrates.
Nitroglycerin In Dextrose label (Baxter Healthcare Company, August 22, 2016), contraindicationsDo not use Nitroglycerin in 5% Dextrose Injection in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors) such as sildenafil, tadalafil, or vardenafil.
Nitroglycerin In Dextrose label (Baxter Healthcare Company, August 22, 2016), drug interactionsConcomitant use of Nitroglycerin in 5% Dextrose Injection with phosphodiesterase inhibitors (e.g. sildenafil, tadalafil, or vardenafil) can cause hypotension and is contraindicated (see Contraindications ).
Nitro-Dur label (Ingenus Pharmaceuticals, LLC, May 30, 2023), contraindicationsDo not use NITRO-DUR in patients who are taking phosphodiesterase inhibitors (such as sildenafil, tadalafil, or vardenafil) for erectile dysfunction or pulmonary arterial hypertension.
Source: FDA drug label (Nitroglycerin In Dextrose, NDA019970), Baxter Healthcare Company, effective August 22, 2016 (SPL set 457a026c-ebce-4701-9deb-2d7652759a99), via openFDA
Source: FDA drug label (Nitrostat), Viatris Specialty LLC, effective February 15, 2023 (SPL set 9a52da75-d0af-4237-96c0-0b12adfa8636), via openFDA; the full label on DailyMed
What does the tadalafil label say about nitroglycerin?
Tadalafil label, warnings and precautionsPhysicians should discuss with patients the appropriate action in the event that they experience anginal chest pain requiring nitroglycerin following intake of CIALIS.
Source: FDA drug label (Cialis), Eli Lilly and Company, effective June 3, 2026 (SPL set bcd8f8ab-81a2-4891-83db-24a0b0e25895), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nitroglycerin | Tadalafil | |
|---|---|---|
| Labeled for | Angina, High blood pressure, Heart failure, Heart attack and coronary artery disease | Erectile dysfunction, Enlarged prostate (BPH), Pulmonary arterial hypertension |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.127 per tablet 0.4 mg tablet sl | $0.167 per tablet 20 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once