Nitroglycerin and Tadalafil Interaction
Drug interaction information between Nitroglycerin and Tadalafil.
Nitroglycerin and Tadalafil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nitroglycerin and Tadalafil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Tadalafil makes the blood-pressure-lowering effects of nitroglycerin much stronger. This can lead to a severe and unsafe decrease in your blood pressure.
FDA Label Information
PDE-5-Inhibitors such as avanafil, sildenafil, vardenafil, and tadalafil have been shown to potentiate the hypotensive effects of organic nitrates.
Nitroglycerin Also Interacts With
- Dapsone Topical moderate
- Lidocaine Topical moderate
- Aspirin minor
- Sildenafil minor
- Heparin minor
Tadalafil Also Interacts With
- Hydralazine/Isosorbide Dinitrate major
- Clarithromycin moderate
- Nirmatrelvir/Ritonavir moderate
- Amlodipine minor
- Metoprolol minor
Frequently Asked Questions
What SPL severity band is on file for Nitroglycerin + Tadalafil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tadalafil has 25 labeled pairs on file vs Nitroglycerin's 8. In the minor band specifically: Nitroglycerin has 6 (also Aspirin, Sildenafil, Heparin, Isradipine); Tadalafil has 22 (also Amlodipine, Metoprolol, Tamsulosin, Aspirin).
What mechanism field is on file for Nitroglycerin and Tadalafil?
Tadalafil makes the blood-pressure-lowering effects of nitroglycerin much stronger. This can lead to a severe and unsafe decrease in your blood pressure.
Tadalafil carries more major-labeled pairs than Nitroglycerin
SPL source-record counts only. This page's band is minor · classes on file: Nitroglycerin (Nitrate Vasodilator); Tadalafil (PDE5 Inhibitor).
Tadalafil has 1 major-labeled pair vs Nitroglycerin's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 6 minor · 8 total
- Other minor peers for Nitroglycerin
- Aspirin
- Sildenafil
- Heparin
- Isradipine
1 major · 2 moderate · 22 minor · 25 total
- Other minor peers for Tadalafil
- Amlodipine
- Metoprolol
- Tamsulosin
- Aspirin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.