Nitroglycerin and Sildenafil Interaction
Drug interaction information between Nitroglycerin and Sildenafil.
Nitroglycerin and Sildenafil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nitroglycerin and Sildenafil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs work to relax and widen your blood vessels. Taking them together can cause your blood pressure to drop to a dangerously low level.
FDA Label Information
PDE-5-Inhibitors such as avanafil, sildenafil, vardenafil, and tadalafil have been shown to potentiate the hypotensive effects of organic nitrates.
Nitroglycerin Also Interacts With
- Dapsone Topical moderate
- Lidocaine Topical moderate
- Aspirin minor
- Tadalafil minor
- Heparin minor
Sildenafil Also Interacts With
- Ketoconazole major
- Erythromycin major
- Itraconazole major
- Darunavir major
- Hydralazine/Isosorbide Dinitrate major
Frequently Asked Questions
What SPL severity band is on file for Nitroglycerin + Sildenafil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sildenafil has 10 labeled pairs on file vs Nitroglycerin's 8. In the minor band specifically: Nitroglycerin has 6 (also Aspirin, Tadalafil, Heparin, Isradipine); Sildenafil has 3 (also Amlodipine, Amlodipine/Valsartan).
What mechanism field is on file for Nitroglycerin and Sildenafil?
Both of these drugs work to relax and widen your blood vessels. Taking them together can cause your blood pressure to drop to a dangerously low level.
Sildenafil carries more major-labeled pairs than Nitroglycerin
SPL source-record counts only. This page's band is minor · classes on file: Nitroglycerin (Nitrate Vasodilator); Sildenafil (PDE5 Inhibitor).
Sildenafil has 6 major-labeled pairs vs Nitroglycerin's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 6 minor · 8 total
- Other minor peers for Nitroglycerin
- Aspirin
- Tadalafil
- Heparin
- Isradipine
6 major · 1 moderate · 3 minor · 10 total
- Other minor peers for Sildenafil
- Amlodipine
- Amlodipine/Valsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.