Nitroglycerin and Dapsone Topical Interaction
Drug interaction information between Nitroglycerin and Dapsone Topical.
Nitroglycerin and Dapsone Topical have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Nitroglycerin and Dapsone Topical. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs can both cause a buildup of a specific type of hemoglobin that does not carry oxygen effectively. Taking them together adds to this risk.
FDA Label Information
7.4 Concomitant Use with Drugs that Induce Methemoglobinemia Concomitant use of ACZONE Gel, 7.5% with drugs that induce methemoglobinemia such as sulfonamides, acetaminophen, acetanilide, aniline dyes, benzocaine, chloroquine, dapsone, naphthalene, nitrates and nitrites, nitrofurantoin, nitroglycerin, nitroprusside, pamaquine, para‐aminosalicylic acid, phenacetin, phenobarbital, phenytoin, primaquine, and quinine may increase the risk for developing methemoglobinemia [see Warnings and Precautions ( 5.1 )] .
Nitroglycerin Also Interacts With
- Lidocaine Topical moderate
- Aspirin minor
- Sildenafil minor
- Tadalafil minor
- Heparin minor
Dapsone Topical Also Interacts With
- Acetaminophen moderate
- Nitrofurantoin moderate
- Chloroquine moderate
- Phenytoin moderate
- Phenobarbital moderate
Frequently Asked Questions
What SPL severity band is on file for Nitroglycerin + Dapsone Topical?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dapsone Topical has 10 labeled pairs on file vs Nitroglycerin's 8. In the moderate band specifically: Nitroglycerin has 2 (also Lidocaine Topical); Dapsone Topical has 6 (also Acetaminophen, Nitrofurantoin, Chloroquine, Phenytoin).
What mechanism field is on file for Nitroglycerin and Dapsone Topical?
These drugs can both cause a buildup of a specific type of hemoglobin that does not carry oxygen effectively. Taking them together adds to this risk.
Dapsone Topical's labeled portfolio outnumbers Nitroglycerin
SPL source-record counts only. This page's band is moderate · classes on file: Nitroglycerin (Nitrate Vasodilator); Dapsone Topical (Topical Anti-Inflammatory).
0 major · 2 moderate · 6 minor · 8 total
- Other moderate peers for Nitroglycerin
- Lidocaine Topical
0 major · 6 moderate · 4 minor · 10 total
- Other moderate peers for Dapsone Topical
- Acetaminophen
- Nitrofurantoin
- Chloroquine
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.