Nitroglycerin and Aspirin Interaction
Drug interaction information between Nitroglycerin and Aspirin.
Nitroglycerin and Aspirin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nitroglycerin and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking high doses of aspirin can increase the amount of nitroglycerin in your blood. This makes the nitroglycerin work more strongly to widen your blood vessels and lower your blood pressure.
FDA Label Information
Drug interactions Aspirin: Coadministration of nitroglycerin with high dose aspirin (1000 mg) results in increased exposure to nitroglycerin. The vasodilatory and hemodynamic effects of nitroglycerin may be enhanced by concomitant administration of nitroglycerin with high dose aspirin.
Nitroglycerin Also Interacts With
- Dapsone Topical moderate
- Lidocaine Topical moderate
- Sildenafil minor
- Tadalafil minor
- Heparin minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Nitroglycerin + Aspirin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Nitroglycerin's 8. In the minor band specifically: Nitroglycerin has 6 (also Sildenafil, Tadalafil, Heparin, Isradipine); Aspirin has 32 (also Carisoprodol, Celecoxib, Colestipol, Diflunisal).
What mechanism field is on file for Nitroglycerin and Aspirin?
Taking high doses of aspirin can increase the amount of nitroglycerin in your blood. This makes the nitroglycerin work more strongly to widen your blood vessels and lower your blood pressure.
Aspirin carries more major-labeled pairs than Nitroglycerin
SPL source-record counts only. This page's band is minor · classes on file: Nitroglycerin (Nitrate Vasodilator); Aspirin (Antiplatelet / NSAID).
Aspirin has 3 major-labeled pairs vs Nitroglycerin's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 6 minor · 8 total
- Other minor peers for Nitroglycerin
- Sildenafil
- Tadalafil
- Heparin
- Isradipine
3 major · 12 moderate · 32 minor · 47 total
- Other minor peers for Aspirin
- Carisoprodol
- Celecoxib
- Colestipol
- Diflunisal
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.