What the FDA labels say about taking them together
Aspirin and nitroglycerin
Nitroglycerin's FDA label of February 15, 2023 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name nitroglycerin. The nitroglycerin label: “Drug interactions Aspirin Coadministration of nitroglycerin with high dose aspirin (1000 mg) results in increased exposure to nitroglycerin.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the nitroglycerin FDA label on DailyMed (effective February 15, 2023, Viatris Specialty LLC).
What does the aspirin label say about nitroglycerin?
Aspirin's label (effective September 9, 2025) does not name nitroglycerin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the nitroglycerin label say about aspirin?
Nitroglycerin label, drug interactionsDrug interactions Aspirin Coadministration of nitroglycerin with high dose aspirin (1000 mg) results in increased exposure to nitroglycerin.
Rectiv label (Allergan, Inc., September 8, 2026), drug interactionsDRUG INTERACTIONS PDE5 inhibitors: potentiation of hypotensive effects of organic nitrates; concomitant use is contraindicated. ( 4.1 , 7.1 ) Antihypertensives: possible additive hypotensive effects. ( 7.2 ) Aspirin: increased nitroglycerin levels. ( 7.3 ) Tissue-type Plasminogen Activator (t-PA): decreased thrombolytic effect. ( 7.4 ) Heparin: anticoagulant effect of heparin may be reduced.
Source: FDA drug label (Rectiv, NDA021359), Allergan, Inc., effective September 8, 2026 (SPL set 603aa9ed-54c4-4a35-ade4-690fa44850e4), via openFDA
Source: FDA drug label (Nitrostat), Viatris Specialty LLC, effective February 15, 2023 (SPL set 9a52da75-d0af-4237-96c0-0b12adfa8636), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Nitroglycerin | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Angina, High blood pressure, Heart failure, Heart attack and coronary artery disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.127 per tablet 0.4 mg tablet sl |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once