What the FDA labels say about taking them together
Clopidogrel and nirmatrelvir/ritonavir
Nirmatrelvir/ritonavir's FDA label of February 19, 2026 names clopidogrel in its drug interactions section; the clopidogrel label PlainMeds reads does not name nirmatrelvir/ritonavir. The nirmatrelvir/ritonavir label: “Avoid concomitant use with PAXLOVID.”
Check it at the source: the clopidogrel FDA label on DailyMed (effective May 30, 2025, Sanofi-Aventis U.S. LLC); the nirmatrelvir/ritonavir FDA label on DailyMed (effective February 19, 2026, Pfizer Laboratories Div Pfizer Inc).
What does the clopidogrel label say about nirmatrelvir/ritonavir?
Clopidogrel's label (effective May 30, 2025) does not name nirmatrelvir/ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Plavix), Sanofi-Aventis U.S. LLC, effective May 30, 2025 (SPL set de8b0b67-eb25-4684-83b5-7ad785314227), via openFDA; the full label on DailyMed
What does the nirmatrelvir/ritonavir label say about clopidogrel?
Nirmatrelvir/ritonavir label, drug interactionsDrug Class: Cardiovascular agents; Drugs within Class: aliskiren, ticagrelor, vorapaxar clopidogrel; Effect on Concentration: ↑ aliskiren ↑ ticagrelor ↑ vorapaxar ↓ clopidogrel active metabolite; Clinical Comments: Avoid concomitant use with PAXLOVID.
Source: FDA drug label (Paxlovid), Pfizer Laboratories Div Pfizer Inc, effective February 19, 2026 (SPL set 8a99d6d6-fd9e-45bb-b1bf-48c7f761232a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clopidogrel | Nirmatrelvir/ritonavir | |
|---|---|---|
| Labeled for | Heart attack and coronary artery disease, Angina | COVID-19 |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0472 per tablet 75 mg tablet | $49.24 per unit 300-100 mg dose pack |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once