Nirmatrelvir/Ritonavir and Clopidogrel Interaction
Drug interaction information between Nirmatrelvir/Ritonavir and Clopidogrel.
Nirmatrelvir/Ritonavir and Clopidogrel have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Nirmatrelvir/Ritonavir and Clopidogrel. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Paxlovid prevents clopidogrel from being turned into its active form in your body. This means the medicine will not work as well to prevent blood clots.
FDA Label Information
Cardiovascular agents aliskiren, ticagrelor, vorapaxar clopidogrel ↑ aliskiren ↑ ticagrelor ↑ vorapaxar ↓ clopidogrel active metabolite Avoid concomitant use with PAXLOVID.
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Clopidogrel Also Interacts With
- Omeprazole moderate
- Warfarin moderate
- Esomeprazole moderate
- Rifampin moderate
- Norepinephrine moderate
Frequently Asked Questions
What SPL severity band is on file for Nirmatrelvir/Ritonavir + Clopidogrel?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Clopidogrel's 19. In the moderate band specifically: Nirmatrelvir/Ritonavir has 30 (also Amlodipine, Tamsulosin, Fluticasone, Apixaban); Clopidogrel has 9 (also Omeprazole, Warfarin, Esomeprazole, Rifampin).
What mechanism field is on file for Nirmatrelvir/Ritonavir and Clopidogrel?
Paxlovid prevents clopidogrel from being turned into its active form in your body. This means the medicine will not work as well to prevent blood clots.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Clopidogrel
SPL source-record counts only. This page's band is moderate · classes on file: Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)); Clopidogrel (Antiplatelet Agent).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Clopidogrel's 0. This page itself is in the moderate band, not the major band.
23 major · 30 moderate · 33 minor · 86 total
- Other moderate peers for Nirmatrelvir/Ritonavir
- Amlodipine
- Tamsulosin
- Fluticasone
- Apixaban
0 major · 9 moderate · 10 minor · 19 total
- Other moderate peers for Clopidogrel
- Omeprazole
- Warfarin
- Esomeprazole
- Rifampin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.