Buspirone and Citalopram Interaction
Drug interaction information between Buspirone and Citalopram.
Buspirone and Citalopram have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Buspirone and Citalopram. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications increase a brain chemical called serotonin. Using them together can cause serotonin levels to rise too high.
FDA Label Information
Other Serotonergic Drugs Clinical Impact: Concomitant use of citalopram and other serotonergic drugs (including other SSRIs, SNRIs, triptans, tricyclic antidepressants, opioids, lithium, buspirone, amphetamines, tryptophan, and St.
Buspirone Also Interacts With
- Tranylcypromine moderate
- Ziprasidone moderate
- Darunavir minor
- Desvenlafaxine minor
- Diltiazem minor
Citalopram Also Interacts With
- Linezolid major
- Pimozide major
- Escitalopram major
- Warfarin moderate
- Phenelzine moderate
Frequently Asked Questions
What SPL severity band is on file for Buspirone + Citalopram?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Buspirone has 17 labeled pairs on file vs Citalopram's 9. In the minor band specifically: Buspirone has 15 (also Darunavir, Desvenlafaxine, Diltiazem, Diphenoxylate/Atropine); Citalopram has 4 (also Lithium, Carbamazepine, Sertraline).
What mechanism field is on file for Buspirone and Citalopram?
Both of these medications increase a brain chemical called serotonin. Using them together can cause serotonin levels to rise too high.
Citalopram carries more major-labeled pairs than Buspirone
SPL source-record counts only. This page's band is minor · classes on file: Buspirone (Azapirone Anxiolytic); Citalopram (Selective Serotonin Reuptake Inhibitor (SSRI)).
Citalopram has 3 major-labeled pairs vs Buspirone's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Buspirone
- Darunavir
- Desvenlafaxine
- Diltiazem
- Diphenoxylate/Atropine
3 major · 2 moderate · 4 minor · 9 total
- Other minor peers for Citalopram
- Lithium
- Carbamazepine
- Sertraline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.