Buspirone and Ziprasidone Interaction
Drug interaction information between Buspirone and Ziprasidone.
Buspirone and Ziprasidone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Buspirone and Ziprasidone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs increase a chemical in the brain called serotonin. Having too much serotonin can lead to a dangerous condition called serotonin syndrome.
FDA Label Information
Risk of serotonin syndrome with concomitant therapy with other serotonergic drugs such as SNRIs, SSRIs, triptans, tricyclic antidepressants, opioids, lithium, tryptophan, buspirone, amphetamines, and St.
Buspirone Also Interacts With
- Tranylcypromine moderate
- Citalopram minor
- Darunavir minor
- Desvenlafaxine minor
- Diltiazem minor
Ziprasidone Also Interacts With
- Lithium moderate
- Tetrabenazine moderate
- Estradiol minor
- Propranolol minor
- Lorazepam minor
Frequently Asked Questions
What SPL severity band is on file for Buspirone + Ziprasidone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ziprasidone has 18 labeled pairs on file vs Buspirone's 17. In the moderate band specifically: Buspirone has 2 (also Tranylcypromine); Ziprasidone has 3 (also Lithium, Tetrabenazine).
What mechanism field is on file for Buspirone and Ziprasidone?
Both of these drugs increase a chemical in the brain called serotonin. Having too much serotonin can lead to a dangerous condition called serotonin syndrome.
Ziprasidone's labeled portfolio outnumbers Buspirone
SPL source-record counts only. This page's band is moderate · classes on file: Buspirone (Azapirone Anxiolytic); Ziprasidone (Atypical Antipsychotic).
0 major · 2 moderate · 15 minor · 17 total
- Other moderate peers for Buspirone
- Tranylcypromine
0 major · 3 moderate · 15 minor · 18 total
- Other moderate peers for Ziprasidone
- Lithium
- Tetrabenazine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.