Buspirone and Darunavir Interaction
Drug interaction information between Buspirone and Darunavir.
Buspirone and Darunavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Buspirone and Darunavir. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Darunavir blocks the enzyme that breaks down buspirone, which can lead to higher levels of the medication in your blood.
What To Do
Your doctor should consider starting with a lower dose of buspirone and monitor you closely for side effects.
FDA Label Information
buspirone, diazepam, estazolam, zolpidem ↑ sedatives/hypnotics Titration is recommended when co-administering darunavir/ritonavir with sedatives/hypnotics metabolized by CYP3A and a lower dose of the sedatives/hypnotics should be considered with monitoring for adverse events.
Buspirone Also Interacts With
- Tranylcypromine moderate
- Ziprasidone moderate
- Citalopram minor
- Desvenlafaxine minor
- Diltiazem minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
Can I take Buspirone and Darunavir together?
This is a minor interaction. Your doctor should consider starting with a lower dose of buspirone and monitor you closely for side effects.
How serious is the interaction between Buspirone and Darunavir?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Buspirone and Darunavir interact?
Darunavir blocks the enzyme that breaks down buspirone, which can lead to higher levels of the medication in your blood.
Understanding the Buspirone and Darunavir Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Buspirone belongs to the Azapirone Anxiolytic class and Darunavir belongs to the HIV Protease Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Darunavir blocks the enzyme that breaks down buspirone, which can lead to higher levels of the medication in your blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Buspirone has 17 total documented interactions on file in this dataset, and Darunavir has 101. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should consider starting with a lower dose of buspirone and monitor you closely for side effects. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Buspirone or Darunavir based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.