Buspirone and Darunavir Interaction
Drug interaction information between Buspirone and Darunavir.
Buspirone and Darunavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Buspirone and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir blocks the enzyme that breaks down buspirone, which can lead to higher levels of the medication in your blood.
FDA Label Information
buspirone, diazepam, estazolam, zolpidem ↑ sedatives/hypnotics Titration is recommended when co-administering darunavir/ritonavir with sedatives/hypnotics metabolized by CYP3A and a lower dose of the sedatives/hypnotics should be considered with monitoring for adverse events.
Buspirone Also Interacts With
- Tranylcypromine moderate
- Ziprasidone moderate
- Citalopram minor
- Desvenlafaxine minor
- Diltiazem minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Buspirone + Darunavir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Buspirone's 17. In the minor band specifically: Buspirone has 15 (also Citalopram, Desvenlafaxine, Diltiazem, Diphenoxylate/Atropine); Darunavir has 70 (also Amlodipine, Metoprolol, Sertraline, Rosuvastatin).
What mechanism field is on file for Buspirone and Darunavir?
Darunavir blocks the enzyme that breaks down buspirone, which can lead to higher levels of the medication in your blood.
Darunavir carries more major-labeled pairs than Buspirone
SPL source-record counts only. This page's band is minor · classes on file: Buspirone (Azapirone Anxiolytic); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Buspirone's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Buspirone
- Citalopram
- Desvenlafaxine
- Diltiazem
- Diphenoxylate/Atropine
15 major · 16 moderate · 70 minor · 101 total
- Other minor peers for Darunavir
- Amlodipine
- Metoprolol
- Sertraline
- Rosuvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.