Buspirone and Desvenlafaxine Interaction
Drug interaction information between Buspirone and Desvenlafaxine.
Buspirone and Desvenlafaxine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Buspirone and Desvenlafaxine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications increase a brain chemical called serotonin, which can cause an additive effect.
FDA Label Information
Examples other SNRIs, SSRIs, triptans, tricyclic antidepressants, opioids, lithium, buspirone, amphetamines, tryptophan, and St.
Buspirone Also Interacts With
- Tranylcypromine moderate
- Ziprasidone moderate
- Citalopram minor
- Darunavir minor
- Diltiazem minor
Desvenlafaxine Also Interacts With
- Aspirin moderate
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Frequently Asked Questions
What SPL severity band is on file for Buspirone + Desvenlafaxine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Desvenlafaxine has 19 labeled pairs on file vs Buspirone's 17. In the minor band specifically: Buspirone has 15 (also Citalopram, Darunavir, Diltiazem, Diphenoxylate/Atropine); Desvenlafaxine has 13 (also Metoprolol, Aripiprazole, Atomoxetine, Lithium).
What mechanism field is on file for Buspirone and Desvenlafaxine?
Both of these medications increase a brain chemical called serotonin, which can cause an additive effect.
Desvenlafaxine's labeled portfolio outnumbers Buspirone
SPL source-record counts only. This page's band is minor · classes on file: Buspirone (Azapirone Anxiolytic); Desvenlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Buspirone
- Citalopram
- Darunavir
- Diltiazem
- Diphenoxylate/Atropine
0 major · 6 moderate · 13 minor · 19 total
- Other minor peers for Desvenlafaxine
- Metoprolol
- Aripiprazole
- Atomoxetine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.