Pitavastatin and Rifampin Interaction
Drug interaction information between Pitavastatin and Rifampin.
Pitavastatin and Rifampin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Pitavastatin and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin causes the levels of pitavastatin in the blood to spike higher than they should. These high levels increase the chance of experiencing dangerous muscle injury.
FDA Label Information
Rifampin Clinical Impact: Rifampin significantly increases peak pitavastatin exposure and increases the risk of myopathy and rhabdomyolysis. Intervention: In patients taking rifampin, do not exceed pitavastatin tablets 2 mg once daily [see Dosage and Administration ( 2.4 )].
Pitavastatin Also Interacts With
- Cyclosporine major
- Erythromycin major
- Colchicine moderate
- Gemfibrozil moderate
- Niacin moderate
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Ranolazine major
Frequently Asked Questions
What SPL severity band is on file for Pitavastatin + Rifampin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Pitavastatin's 9. In the major band specifically: Pitavastatin has 3 (also Cyclosporine, Erythromycin); Rifampin has 8 (also Darunavir, Bictegravir, Glecaprevir/Pibrentasvir, Nirmatrelvir/Ritonavir).
What mechanism field is on file for Pitavastatin and Rifampin?
Rifampin causes the levels of pitavastatin in the blood to spike higher than they should. These high levels increase the chance of experiencing dangerous muscle injury.
Rifampin carries more major-labeled pairs than Pitavastatin
SPL source-record counts only. This page's band is major · classes on file: Pitavastatin (HMG-CoA Reductase Inhibitor (Statin)); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Pitavastatin's 3.
3 major · 4 moderate · 2 minor · 9 total
- Other major peers for Pitavastatin
- Cyclosporine
- Erythromycin
8 major · 26 moderate · 103 minor · 137 total
- Other major peers for Rifampin
- Darunavir
- Bictegravir
- Glecaprevir/Pibrentasvir
- Nirmatrelvir/Ritonavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.