Pitavastatin and Colchicine Interaction
Drug interaction information between Pitavastatin and Colchicine.
Pitavastatin and Colchicine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Pitavastatin and Colchicine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs together can increase the risk of serious muscle damage.
FDA Label Information
Colchicine Clinical Impact: Cases of myopathy and rhabdomyolysis have been reported with concomitant use of colchicine with statins, including pitavastatin tablets. Intervention: Consider the risk/benefit of concomitant use of colchicine with pitavastatin tablets.
Pitavastatin Also Interacts With
- Cyclosporine major
- Erythromycin major
- Rifampin major
- Gemfibrozil moderate
- Niacin moderate
Colchicine Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Pitavastatin + Colchicine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Colchicine has 28 labeled pairs on file vs Pitavastatin's 9. In the moderate band specifically: Pitavastatin has 4 (also Gemfibrozil, Niacin, Sofosbuvir/Velpatasvir); Colchicine has 9 (also Atorvastatin, Ezetimibe, Ezetimibe/Simvastatin, Fenofibrate).
What mechanism field is on file for Pitavastatin and Colchicine?
Taking these two drugs together can increase the risk of serious muscle damage.
Colchicine carries more major-labeled pairs than Pitavastatin
SPL source-record counts only. This page's band is moderate · classes on file: Pitavastatin (HMG-CoA Reductase Inhibitor (Statin)); Colchicine (Anti-Gout Agent).
Colchicine has 4 major-labeled pairs vs Pitavastatin's 3. This page itself is in the moderate band, not the major band.
3 major · 4 moderate · 2 minor · 9 total
- Other moderate peers for Pitavastatin
- Gemfibrozil
- Niacin
- Sofosbuvir/Velpatasvir
4 major · 9 moderate · 15 minor · 28 total
- Other moderate peers for Colchicine
- Atorvastatin
- Ezetimibe
- Ezetimibe/Simvastatin
- Fenofibrate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.