Pitavastatin and Colchicine Interaction
Drug interaction information between Pitavastatin and Colchicine.
Pitavastatin and Colchicine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Pitavastatin and Colchicine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Taking these two drugs together can increase the risk of serious muscle damage.
What To Do
Your doctor should carefully consider if the benefits of taking both drugs are worth the risks.
FDA Label Information
Colchicine Clinical Impact: Cases of myopathy and rhabdomyolysis have been reported with concomitant use of colchicine with statins, including pitavastatin tablets. Intervention: Consider the risk/benefit of concomitant use of colchicine with pitavastatin tablets.
Pitavastatin Also Interacts With
- Cyclosporine major
- Erythromycin major
- Rifampin major
- Gemfibrozil moderate
- Niacin moderate
Colchicine Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
Frequently Asked Questions
Can I take Pitavastatin and Colchicine together?
This is a moderate interaction. Your doctor should carefully consider if the benefits of taking both drugs are worth the risks.
How serious is the interaction between Pitavastatin and Colchicine?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Pitavastatin and Colchicine interact?
Taking these two drugs together can increase the risk of serious muscle damage.
Understanding the Pitavastatin and Colchicine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Pitavastatin belongs to the HMG-CoA Reductase Inhibitor (Statin) class and Colchicine belongs to the Anti-Gout Agent class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Taking these two drugs together can increase the risk of serious muscle damage. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Pitavastatin has 9 total documented interactions on file in this dataset, and Colchicine has 28. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should carefully consider if the benefits of taking both drugs are worth the risks. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Pitavastatin or Colchicine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.