Pitavastatin and Erythromycin Interaction
Drug interaction information between Pitavastatin and Erythromycin.
Pitavastatin and Erythromycin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Pitavastatin and Erythromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin slows down how the body processes pitavastatin, which leads to higher amounts of the drug in your system. Having too much pitavastatin in the blood can cause severe muscle breakdown.
FDA Label Information
Erythromycin Clinical Impact: Erythromycin significantly increases pitavastatin exposure and increases the risk of myopathy and rhabdomyolysis. Intervention: In patients taking erythromycin, do not exceed pitavastatin tablets 1 mg once daily [see Dosage and Administration ( 2.4 )].
Pitavastatin Also Interacts With
- Cyclosporine major
- Rifampin major
- Colchicine moderate
- Gemfibrozil moderate
- Niacin moderate
Erythromycin Also Interacts With
- Eplerenone major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
- Lovastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Pitavastatin + Erythromycin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Pitavastatin's 9. In the major band specifically: Pitavastatin has 3 (also Cyclosporine, Rifampin); Erythromycin has 4 (also Eplerenone, Risperidone, Sildenafil).
What mechanism field is on file for Pitavastatin and Erythromycin?
Erythromycin slows down how the body processes pitavastatin, which leads to higher amounts of the drug in your system. Having too much pitavastatin in the blood can cause severe muscle breakdown.
Erythromycin carries more major-labeled pairs than Pitavastatin
SPL source-record counts only. This page's band is major · classes on file: Pitavastatin (HMG-CoA Reductase Inhibitor (Statin)); Erythromycin (Macrolide Antibiotic).
Erythromycin has 4 major-labeled pairs vs Pitavastatin's 3.
3 major · 4 moderate · 2 minor · 9 total
- Other major peers for Pitavastatin
- Cyclosporine
- Rifampin
4 major · 6 moderate · 53 minor · 63 total
- Other major peers for Erythromycin
- Eplerenone
- Risperidone
- Sildenafil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.