Pitavastatin and Gemfibrozil Interaction
Drug interaction information between Pitavastatin and Gemfibrozil.
Pitavastatin and Gemfibrozil have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Pitavastatin and Gemfibrozil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Gemfibrozil can cause muscle problems on its own, and the risk becomes even higher when it is mixed with a statin.
FDA Label Information
Gemfibrozil Clinical Impact: Gemfibrozil may cause myopathy when given alone. The risk of myopathy and rhabdomyolysis is increased with concomitant use of gemfibrozil with statins, including pitavastatin tablets. Intervention: Avoid concomitant use of gemfibrozil with pitavastatin tablets.
Pitavastatin Also Interacts With
- Cyclosporine major
- Erythromycin major
- Rifampin major
- Colchicine moderate
- Niacin moderate
Gemfibrozil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Repaglinide major
- Simvastatin major
- Atorvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Pitavastatin + Gemfibrozil?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Gemfibrozil has 20 labeled pairs on file vs Pitavastatin's 9. In the moderate band specifically: Pitavastatin has 4 (also Colchicine, Niacin, Sofosbuvir/Velpatasvir); Gemfibrozil has 8 (also Atorvastatin, Eluxadoline, Fluvastatin, Lovastatin).
What mechanism field is on file for Pitavastatin and Gemfibrozil?
Gemfibrozil can cause muscle problems on its own, and the risk becomes even higher when it is mixed with a statin.
Gemfibrozil carries more major-labeled pairs than Pitavastatin
SPL source-record counts only. This page's band is moderate · classes on file: Pitavastatin (HMG-CoA Reductase Inhibitor (Statin)); Gemfibrozil (Fibrate).
Gemfibrozil has 4 major-labeled pairs vs Pitavastatin's 3. This page itself is in the moderate band, not the major band.
3 major · 4 moderate · 2 minor · 9 total
- Other moderate peers for Pitavastatin
- Colchicine
- Niacin
- Sofosbuvir/Velpatasvir
4 major · 8 moderate · 8 minor · 20 total
- Other moderate peers for Gemfibrozil
- Atorvastatin
- Eluxadoline
- Fluvastatin
- Lovastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.