Nadolol and Itraconazole Interaction

Drug interaction information between Nadolol and Itraconazole.

Nadolol and Itraconazole have a documented minor interaction in FDA labeling.

FDA drug labeling documents a minor-severity interaction between Nadolol and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.

Drug A

Nadolol

Non-Selective Beta-Blocker

Drug B

Itraconazole

Azole Antifungal

How They Interact

Itraconazole can slow down how the body breaks down nadolol, which might lead to higher levels of the beta blocker in the blood.

FDA Label Information

Beta Blockers Nadolol a Monitor for adverse reactions.

Frequently Asked Questions

What SPL severity band is on file for Nadolol + Itraconazole?

Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.

Which drug in this pair has the larger labeled-interaction portfolio?

Itraconazole has 116 labeled pairs on file vs Nadolol's 3. In the minor band specifically: Nadolol has 2 (also Epinephrine); Itraconazole has 77 (also Fluticasone, Meloxicam, Buspirone, Oxycodone).

What mechanism field is on file for Nadolol and Itraconazole?

Itraconazole can slow down how the body breaks down nadolol, which might lead to higher levels of the beta blocker in the blood.

Itraconazole carries more major-labeled pairs than Nadolol

SPL source-record counts only. This page's band is minor · classes on file: Nadolol (Non-Selective Beta-Blocker); Itraconazole (Azole Antifungal).

Itraconazole has 19 major-labeled pairs vs Nadolol's 1. This page itself is in the minor band, not the major band.

Nadolol

1 major · 0 moderate · 2 minor · 3 total

Itraconazole

19 major · 20 moderate · 77 minor · 116 total

Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.