Nadolol and Epinephrine Interaction
Drug interaction information between Nadolol and Epinephrine.
Nadolol and Epinephrine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nadolol and Epinephrine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Nadolol can make your body less responsive to epinephrine, which is the medicine used to treat severe allergic reactions.
FDA Label Information
Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction.
Epinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Digoxin moderate
- Imipramine moderate
- Levothyroxine minor
Frequently Asked Questions
What SPL severity band is on file for Nadolol + Epinephrine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Epinephrine has 28 labeled pairs on file vs Nadolol's 3. In the minor band specifically: Nadolol has 2 (also Itraconazole); Epinephrine has 24 (also Levothyroxine, Clonidine, Theophylline, Oxytocin).
What mechanism field is on file for Nadolol and Epinephrine?
Nadolol can make your body less responsive to epinephrine, which is the medicine used to treat severe allergic reactions.
Epinephrine's labeled portfolio outnumbers Nadolol
SPL source-record counts only. This page's band is minor · classes on file: Nadolol (Non-Selective Beta-Blocker); Epinephrine (Adrenergic Agonist).
1 major · 3 moderate · 24 minor · 28 total
- Other minor peers for Epinephrine
- Levothyroxine
- Clonidine
- Theophylline
- Oxytocin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.