Montelukast and Digoxin Interaction
Drug interaction information between Montelukast and Digoxin.
Montelukast and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Montelukast and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications do not interfere with each other's levels in the blood.
FDA Label Information
DRUG INTERACTIONS No dose adjustment is needed when montelukast sodium is co-administered with theophylline, prednisone, prednisolone, oral contraceptives, terfenadine, digoxin, warfarin, gemfibrozil, itraconazole, thyroid hormones, sedative hypnotics, non-steroidal anti-inflammatory agents, benzodiazepines, decongestants, and Cytochrome P450 (CYP) enzyme inducers [see Clinical Pharmacology (12.3)] .
Montelukast Also Interacts With
- Prednisone minor
- Warfarin minor
- Prednisolone minor
- Itraconazole minor
- Theophylline minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Montelukast + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Montelukast's 8. In the minor band specifically: Montelukast has 8 (also Prednisone, Warfarin, Prednisolone, Itraconazole); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Montelukast and Digoxin?
These medications do not interfere with each other's levels in the blood.
Digoxin carries more major-labeled pairs than Montelukast
SPL source-record counts only. This page's band is minor · classes on file: Montelukast (Leukotriene Receptor Antagonist); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Montelukast's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Montelukast
- Prednisone
- Warfarin
- Prednisolone
- Itraconazole
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.