Montelukast and Theophylline Interaction
Drug interaction information between Montelukast and Theophylline.
Montelukast and Theophylline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Montelukast and Theophylline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs together does not affect how much of either medicine stays in your body.
FDA Label Information
DRUG INTERACTIONS No dose adjustment is needed when montelukast sodium is co-administered with theophylline, prednisone, prednisolone, oral contraceptives, terfenadine, digoxin, warfarin, gemfibrozil, itraconazole, thyroid hormones, sedative hypnotics, non-steroidal anti-inflammatory agents, benzodiazepines, decongestants, and Cytochrome P450 (CYP) enzyme inducers [see Clinical Pharmacology (12.3)] .
Montelukast Also Interacts With
- Prednisone minor
- Warfarin minor
- Prednisolone minor
- Itraconazole minor
- Digoxin minor
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Omeprazole major
- Amoxicillin major
- Famotidine major
Frequently Asked Questions
What SPL severity band is on file for Montelukast + Theophylline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Theophylline has 86 labeled pairs on file vs Montelukast's 8. In the minor band specifically: Montelukast has 8 (also Prednisone, Warfarin, Prednisolone, Itraconazole); Theophylline has 54 (also Propranolol, Methotrexate, Diazepam, Lithium).
What mechanism field is on file for Montelukast and Theophylline?
Taking these two drugs together does not affect how much of either medicine stays in your body.
Theophylline carries more major-labeled pairs than Montelukast
SPL source-record counts only. This page's band is minor · classes on file: Montelukast (Leukotriene Receptor Antagonist); Theophylline (Methylxanthine Bronchodilator).
Theophylline has 27 major-labeled pairs vs Montelukast's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Montelukast
- Prednisone
- Warfarin
- Prednisolone
- Itraconazole
27 major · 5 moderate · 54 minor · 86 total
- Other minor peers for Theophylline
- Propranolol
- Methotrexate
- Diazepam
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.