Montelukast and Warfarin Interaction
Drug interaction information between Montelukast and Warfarin.
Montelukast and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Montelukast and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two medicines do not interfere with each other, so they do not change how the other drug is processed.
FDA Label Information
DRUG INTERACTIONS No dose adjustment is needed when montelukast sodium is co-administered with theophylline, prednisone, prednisolone, oral contraceptives, terfenadine, digoxin, warfarin, gemfibrozil, itraconazole, thyroid hormones, sedative hypnotics, non-steroidal anti-inflammatory agents, benzodiazepines, decongestants, and Cytochrome P450 (CYP) enzyme inducers [see Clinical Pharmacology (12.3)] .
Montelukast Also Interacts With
- Prednisone minor
- Prednisolone minor
- Itraconazole minor
- Digoxin minor
- Theophylline minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Montelukast + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Montelukast's 8. In the minor band specifically: Montelukast has 8 (also Prednisone, Prednisolone, Itraconazole, Digoxin); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Montelukast and Warfarin?
These two medicines do not interfere with each other, so they do not change how the other drug is processed.
Warfarin carries more major-labeled pairs than Montelukast
SPL source-record counts only. This page's band is minor · classes on file: Montelukast (Leukotriene Receptor Antagonist); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Montelukast's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Montelukast
- Prednisone
- Prednisolone
- Itraconazole
- Digoxin
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.